| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Mikael Silvestre | 35 | 33 | 2 | 2 | 1 | 2 |
Paul Scholes | 33 | 29 | 4 | 4 | 7 | 9 |
Cristiano Ronaldo | 33 | 25 | 10 | 8 | 9 | 5 |
Ryan Giggs | 32 | 26 | 6 | 6 | 6 | 6 |
Rio Ferdinand | 31 | 31 | - | - | - | - |
Roy Keane | 31 | 28 | 4 | 3 | 3 | 1 |
Alan Smith | 31 | 22 | 11 | 9 | 4 | 6 |
Wayne Rooney | 29 | 24 | 5 | 5 | 8 | 11 |
Roy Carroll | 26 | 26 | 10 | - | - | - |
Gabriel Heinze | 26 | 26 | - | - | 1 | 1 |
John O'Shea | 23 | 16 | 14 | 7 | 3 | 2 |
Gary Neville | 22 | 22 | 2 | - | 3 | - |
Wes Brown | 21 | 18 | 8 | 3 | 1 | 1 |
Phil Neville | 19 | 12 | 18 | 7 | 3 | - |
Darren Fletcher | 18 | 18 | 3 | - | 11 | 3 |
Ruud van Nistelrooy | 17 | 16 | 1 | 1 | 9 | 6 |
Quinton Fortune | 17 | 12 | 10 | 5 | 4 | - |
Louis Saha | 14 | 7 | 9 | 7 | 3 | 1 |
Tim Howard | 12 | 12 | 19 | - | - | - |
David Bellion | 10 | 1 | 15 | 9 | 1 | 2 |
Kleberson | 8 | 6 | 6 | 2 | 6 | - |
Liam Miller | 8 | 3 | 12 | 5 | 3 | - |
Eric Djemba-Djemba | 5 | 3 | 5 | 2 | 2 | - |
Jonathan Spector | 3 | 2 | 3 | 1 | 1 | - |
Kieran Richardson | 2 | - | 2 | 2 | - | - |
Diego Forlan | 1 | - | 1 | 1 | - | - |
Ricardo | - | - | 9 | - | - | - |
Chris Eagles | - | - | 1 | - | - | - | 507 | 418 | 190 | 89 | 89 | 56 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .