| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 David de Gea | 37 | 37 | - | - | - | - |
Nemanja Matic | 36 | 35 | 1 | 1 | 2 | 1 |
Marcus Rashford | 35 | 17 | 20 | 18 | 10 | 7 |
Romelu Lukaku | 34 | 33 | 1 | 1 | 3 | 16 |
Jesse Lingard | 33 | 20 | 17 | 13 | 17 | 8 |
Luis Antonio Valencia | 31 | 31 | 1 | - | 3 | 3 |
Ashley Young | 30 | 28 | 4 | 2 | 7 | 2 |
Anthony Martial | 30 | 18 | 16 | 12 | 13 | 9 |
Chris Smalling | 29 | 28 | 7 | 1 | - | 4 |
Juan Mata | 28 | 23 | 13 | 5 | 16 | 3 |
Paul Pogba | 27 | 25 | 2 | 2 | 5 | 6 |
Ander Herrera | 26 | 13 | 20 | 13 | 6 | - |
Phil Jones | 23 | 23 | 3 | - | 2 | - |
Victor Lindelof | 17 | 13 | 13 | 4 | - | - |
Marouane Fellaini | 16 | 5 | 11 | 11 | 2 | 4 |
Henrikh Mkhitaryan | 15 | 11 | 5 | 4 | 11 | 1 |
Eric Bailly | 13 | 11 | 7 | 2 | - | 1 |
Scott McTominay | 13 | 7 | 16 | 6 | 1 | - |
Alexis Sanchez | 12 | 12 | 1 | - | 5 | 2 |
Luke Shaw | 11 | 8 | 13 | 3 | 1 | - |
Marcos Rojo | 9 | 8 | 12 | 1 | 3 | - |
Matteo Darmian | 8 | 5 | 12 | 3 | 1 | - |
Daley Blind | 7 | 4 | 14 | 3 | 1 | - |
Zlatan Ibrahimovic | 5 | 1 | 7 | 4 | 1 | - |
Michael Carrick | 2 | 1 | 8 | 1 | 1 | - |
Sergio Romero | 1 | 1 | 29 | - | - | - |
Axel Tuanzebe | 1 | - | 4 | 1 | - | - |
Joel Pereira | - | - | 9 | - | - | - | 529 | 418 | 266 | 111 | 111 | 67 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .