| MD | Players | Nationality | DOB | A(D) |
|---|---|---|---|---|
| 14-Sep-2021 | Yeremi Pino | Spain | 20-Oct-2002 | 18(330) |
| 15-Apr-2009 | Jordi Pablo | Spain | 01-Jan-1990 | 19(104) |
| 18-Oct-2005 | Cesar Arzo | Spain | 21-Jan-1986 | 19(270) |
| 02-Nov-2011 | Joselu | Spain | 03-Mar-1991 | 20(244) |
| 14-Sep-2011 | Mario Gaspar | Spain | 24-Nov-1990 | 20(294) |
| 18-Oct-2005 | Santi Cazorla | Spain | 13-Dec-1984 | 20(309) |
| 14-Sep-2011 | Mateo Musacchio | Argentina | 26-Aug-1990 | 21(19) |
| 27-Sep-2011 | Mubarak Wakaso | Ghana | 25-Jul-1990 | 21(64) |
| 14-Sep-2005 | Hector Font | Spain | 15-Jun-1984 | 21(91) |
| 02-Nov-2005 | Mariano Barbosa | Argentina | 27-Jul-1984 | 21(98) |
| 14-Sep-2005 | Gonzalo Rodriguez | Argentina | 10-Apr-1984 | 21(157) |
| 30-Sep-2008 | Giuseppe Rossi | Italy | 01-Feb-1987 | 21(242) |
| 17-Sep-2008 | Matias Fernandez | Chile | 15-May-1986 | 22(126) |
| 20-Oct-2021 | Samuel Chukwueze | Nigeria | 22-May-1999 | 22(152) |
| 07-Apr-2009 | Marco Ruben | Argentina | 26-Oct-1986 | 22(164) |
| 14-Sep-2005 | Sebastian Viera | Uruguay | 07-Mar-1983 | 22(192) |
| 27-Sep-2011 | Hernan Perez | Paraguay | 25-Feb-1989 | 22(214) |
| 18-Oct-2011 | Marcos Gullon | Spain | 20-Feb-1989 | 22(240) |
| 17-Sep-2008 | Diego Godin | Uruguay | 16-Jan-1986 | 22(245) |
| 14-Sep-2021 | Juan Foyth | Argentina | 12-Jan-1998 | 23(245) |
| 29-Sep-2021 | Pervis Estupinan | Ecuador | 21-Jan-1998 | 23(251) |
| 14-Sep-2011 | Jonathan De Guzman | Netherlands | 13-Sep-1987 | 24(1) |
| 30-Sep-2008 | Bruno Soriano | Spain | 12-Jul-1984 | 24(80) |
| 14-Sep-2005 | Luciano Figueroa | Argentina | 19-May-1981 | 24(118) |
| 14-Sep-2021 | Arnaut Danjuma | Netherlands | 31-Jan-1997 | 24(226) |
| 14-Sep-2021 | Pau Torres | Spain | 16-Jan-1997 | 24(241) |
| 14-Sep-2021 | Boulaye Dia | Senegal | 16-Nov-1996 | 24(302) |
| 14-Sep-2005 | Antonio Guayre | Spain | 03-Oct-1980 | 24(346) |
| 02-Nov-2011 | Joan Oriol | Spain | 05-Nov-1986 | 24(362) |
| 14-Sep-2005 | Jan Kromkamp | Netherlands | 17-Aug-1980 | 25(28) |
| 22-Nov-2005 | Xisco | Spain | 05-Sep-1980 | 25(78) |
| 14-Sep-2021 | Alfonso Pedraza | Spain | 09-Apr-1996 | 25(158) |
| 22-Feb-2022 | Giovani Lo Celso | Argentina | 09-Apr-1996 | 25(319) |
| 14-Sep-2005 | Diego Forlan | Uruguay | 19-May-1979 | 26(119) |
| 14-Sep-2011 | Jose Catala | Spain | 01-Jan-1985 | 26(256) |
| 18-Oct-2011 | Borja Valero | Spain | 12-Jan-1985 | 26(279) |
| 18-Oct-2005 | Jose Maria Romero | Spain | 10-Dec-1978 | 26(313) |
| 17-Sep-2008 | Diego Lopez | Spain | 03-Nov-1981 | 26(319) |
| 23-Nov-2021 | Daniel Raba | Spain | 01-Jan-1995 | 26(327) |
| 02-Nov-2005 | Jose Mari | Spain | 10-Dec-1978 | 26(328) |
| 14-Sep-2021 | Moises Gomez | Spain | 20-Oct-1994 | 26(330) |
| 17-Sep-2008 | Cani | Spain | 03-Aug-1981 | 27(45) |
| 14-Sep-2011 | Nilmar | Brazil | 14-Jul-1984 | 27(61) |
| 27-Sep-2005 | Juan Roman Riquelme | Argentina | 24-Jun-1978 | 27(95) |
| 17-Sep-2008 | Angel Lopez | Spain | 10-Mar-1981 | 27(191) |
| 17-Sep-2008 | Sebastian Eguren | Uruguay | 08-Jan-1981 | 27(252) |
| 07-Mar-2006 | Javier Calleja | Spain | 12-May-1978 | 27(299) |
| 29-Sep-2021 | Paco Alcacer | Spain | 30-Aug-1993 | 28(30) |
| 14-Sep-2005 | Roger | Spain | 15-Dec-1976 | 28(273) |
| 17-Sep-2008 | Joseba Llorente | Spain | 24-Nov-1979 | 28(298) |
MD = Match date,
DOB = Date Of Birth,
A(D) = Age(Days).