| 6 | Dries Mertens | Group Stage | UEFA Champions League 19/20 |
| 5 | Victor Osimhen | Group Stage | UEFA Champions League 22/23 |
| 5 | Dries Mertens | Group Stage | UEFA Champions League 16/17 |
| 5 | Edinson Cavani | Group Stage | UEFA Champions League 11/12 |
| 4 | Giacomo Raspadori | Group Stage | UEFA Champions League 22/23 |
| 4 | Giovanni Simeone | Group Stage | UEFA Champions League 22/23 |
| 4 | Piotr Zielinski | Group Stage | UEFA Champions League 22/23 |
| 4 | Gonzalo Higuain | Group Stage | UEFA Champions League 13/14 |
| 3 | Arkadiusz Milik | Group Stage | UEFA Champions League 19/20 |
| 3 | Lorenzo Insigne | Group Stage | UEFA Champions League 17/18 |
| 3 | Arkadiusz Milik | Group Stage | UEFA Champions League 16/17 |
| 2 | Giovanni Di Lorenzo | Group Stage | UEFA Champions League 22/23 |
| 2 | Khvicha Kvaratskhelia | Group Stage | UEFA Champions League 22/23 |
| 2 | Lorenzo Insigne | Group Stage | UEFA Champions League 19/20 |
| 2 | Dries Mertens | Group Stage | UEFA Champions League 18/19 |
| 2 | Lorenzo Insigne | Group Stage | UEFA Champions League 18/19 |
| 2 | Piotr Zielinski | Group Stage | UEFA Champions League 17/18 |
| 2 | Dries Mertens | Group Stage | UEFA Champions League 17/18 |
| 2 | Marek Hamsik | Group Stage | UEFA Champions League 16/17 |
| 2 | Victor Osimhen | Group Section | UEFA Champions League 23/24 |
| 2 | Lorenzo Insigne | Group Stage | UEFA Champions League 13/14 |
| 2 | Jose Callejon | Group Stage | UEFA Champions League 13/14 |
| 2 | Ezequiel Ivan Lavezzi | Round of 16 | UEFA Champions League 11/12 |
| 2 | Marek Hamsik | Group Stage | UEFA Champions League 11/12 |
| 2 | Federico Fernandez | Group Stage | UEFA Champions League 11/12 |
| 2 | Gokhan Inler | Group Stage | UEFA Champions League 11/12 |
| 1 | Frank Anguissa | Group Stage | UEFA Champions League 22/23 |
| 1 | Leo Ostigard | Group Stage | UEFA Champions League 22/23 |
| 1 | Matteo Politano | Group Stage | UEFA Champions League 22/23 |
| 1 | Tanguy NDombele | Group Stage | UEFA Champions League 22/23 |
| 1 | Hirving Lozano | Group Stage | UEFA Champions League 22/23 |
| 1 | Hirving Lozano | Group Stage | UEFA Champions League 19/20 |
| 1 | Fernando Llorente | Group Stage | UEFA Champions League 19/20 |
| 1 | Marek Hamsik | Group Stage | UEFA Champions League 18/19 |
| 1 | Arkadiusz Milik | Group Stage | UEFA Champions League 17/18 |
| 1 | Amadou Diawara | Group Stage | UEFA Champions League 17/18 |
| 1 | Jorginho | Group Stage | UEFA Champions League 17/18 |
| 1 | Jose Callejon | Group Stage | UEFA Champions League 17/18 |
| 1 | Manolo Gabbiadini | Group Stage | UEFA Champions League 16/17 |
| 1 | Jose Callejon | Group Stage | UEFA Champions League 16/17 |
| 1 | Lorenzo Insigne | Round of 16 | UEFA Champions League 16/17 |
| 1 | Leo Ostigard | Group Section | UEFA Champions League 23/24 |
| 1 | Giovanni Simeone | Group Section | UEFA Champions League 23/24 |
| 1 | Giacomo Raspadori | Group Section | UEFA Champions League 23/24 |
| 1 | Giovanni Di Lorenzo | Group Section | UEFA Champions League 23/24 |
| 1 | Matteo Politano | Group Section | UEFA Champions League 23/24 |
| 1 | Amir Rrahmani | Round of 16 | UEFA Champions League 23/24 |
| 1 | Piotr Zielinski | Group Section | UEFA Champions League 23/24 |
| 1 | Frank Anguissa | Group Section | UEFA Champions League 23/24 |
| 1 | Duvan Zapata | Group Stage | UEFA Champions League 13/14 |
| 1 | Gokhan Inler | Group Stage | UEFA Champions League 13/14 |
