| 8 | Edin Dzeko | Group Stage | UEFA Champions League 17/18 |
| 5 | Edin Dzeko | Group Stage | UEFA Champions League 18/19 |
| 4 | Marco Borriello | Group Stage | UEFA Champions League 10/11 |
| 4 | Mirko Vucinic | Group Stage | UEFA Champions League 07/08 |
| 4 | Francesco Totti | Group Stage | UEFA Champions League 06/07 |
| 4 | Antonio Cassano | First Group Stage | UEFA Champions League 02/03 |
| 3 | Cengiz Under | Group Stage | UEFA Champions League 18/19 |
| 3 | Diego Perotti | Group Stage | UEFA Champions League 17/18 |
| 3 | Gervinho | Group Stage | UEFA Champions League 14/15 |
| 3 | Matteo Brighi | Group Stage | UEFA Champions League 08/09 |
| 3 | Mirko Vucinic | Group Stage | UEFA Champions League 08/09 |
| 3 | Francesco Totti | First Group Stage | UEFA Champions League 02/03 |
| 3 | Francesco Totti | First Group Stage | UEFA Champions League 01/02 |
| 2 | Nicolo Zaniolo | Round of 16 | UEFA Champions League 18/19 |
| 2 | Stephan El Shaaraway | Group Stage | UEFA Champions League 17/18 |
| 2 | Radja Nainggolan | Semi-Finals | UEFA Champions League 17/18 |
| 2 | Kostas Manolas | Group Stage | UEFA Champions League 17/18 |
| 2 | Edin Dzeko | Group Stage | UEFA Champions League 15/16 |
| 2 | Daniele De Rossi | Group Stage | UEFA Champions League 15/16 |
| 2 | Miralem Pjanic | Group Stage | UEFA Champions League 15/16 |
| 2 | Francesco Totti | Group Stage | UEFA Champions League 14/15 |
| 2 | Francesco Totti | Group Stage | UEFA Champions League 10/11 |
| 2 | Jeremy Menez | Group Stage | UEFA Champions League 10/11 |
| 2 | Francesco Totti | Group Stage | UEFA Champions League 08/09 |
| 2 | Christian Panucci | Group Stage | UEFA Champions League 08/09 |
| 2 | Julio Baptista | Group Stage | UEFA Champions League 08/09 |
| 2 | Mancini | Group Stage | UEFA Champions League 07/08 |
| 2 | Daniele De Rossi | Group Stage | UEFA Champions League 06/07 |
| 2 | Rodrigo Taddei | Group Stage | UEFA Champions League 06/07 |
| 2 | Cafu | First Group Stage | UEFA Champions League 01/02 |
| 2 | Emerson | Second Group Stage | UEFA Champions League 01/02 |
| 1 | Justin Kluivert | Group Stage | UEFA Champions League 18/19 |
| 1 | Daniele De Rossi | Round of 16 | UEFA Champions League 18/19 |
| 1 | Kostas Manolas | Group Stage | UEFA Champions League 18/19 |
| 1 | Lorenzo Pellegrini | Group Stage | UEFA Champions League 18/19 |
| 1 | Aleksandar Kolarov | Group Stage | UEFA Champions League 17/18 |
| 1 | Daniele De Rossi | Quarter-finals | UEFA Champions League 17/18 |
| 1 | Cengiz Under | Round of 16 | UEFA Champions League 17/18 |
| 1 | Vasilis Torosidis | Group Stage | UEFA Champions League 15/16 |
| 1 | Mohamed Salah | Group Stage | UEFA Champions League 15/16 |
| 1 | Alessandro Florenzi | Group Stage | UEFA Champions League 15/16 |
| 1 | Gervinho | Group Stage | UEFA Champions League 15/16 |
| 1 | Iago Falque | Group Stage | UEFA Champions League 15/16 |
| 1 | Juan Iturbe | Group Stage | UEFA Champions League 14/15 |
| 1 | Maicon | Group Stage | UEFA Champions League 14/15 |
| 1 | Daniele De Rossi | Group Stage | UEFA Champions League 10/11 |
| 1 | Simone Perrotta | Round of 16 | UEFA Champions League 10/11 |
| 1 | Philippe Mexes | Group Stage | UEFA Champions League 10/11 |
| 1 | Leandro Greco | Group Stage | UEFA Champions League 10/11 |
| 1 | Juan | Round of 16 | UEFA Champions League 08/09 |
| 1 | Simone Perrotta | Group Stage | UEFA Champions League 07/08 |
| 1 | Christian Panucci | Group Stage | UEFA Champions League 07/08 |
| 1 | Rodrigo Taddei | Round of 16 | UEFA Champions League 07/08 |
| 1 | Ludovic Giuly | Group Stage | UEFA Champions League 07/08 |
| 1 | Juan | Group Stage | UEFA Champions League 07/08 |
| 1 | Francesco Totti | Group Stage | UEFA Champions League 07/08 |
| 1 | Marco Cassetti | Group Stage | UEFA Champions League 07/08 |
| 1 | David Pizarro | Round of 16 | UEFA Champions League 07/08 |
| 1 | David Pizarro | Group Stage | UEFA Champions League 06/07 |
| 1 | Christian Panucci | Group Stage | UEFA Champions League 06/07 |
