| 11 | Sebastien Haller | Group Stage | UEFA Champions League 21/22 |
| 9 | Jari Litmanen | Group Stage | UEFA Champions League 95/96 |
| 6 | Dusan Tadic | Group Stage | UEFA Champions League 18/19 |
| 6 | Jari Litmanen | Semi-finals | UEFA Champions League 94/95 |
| 5 | Patrick Kluivert | Group Stage | UEFA Champions League 95/96 |
| 5 | Zlatan Ibrahimovic | First Group Stage | UEFA Champions League 02/03 |
| 4 | Mohammed Kudus | Group Stage | UEFA Champions League 22/23 |
| 4 | Quincy Promes | Group Stage | UEFA Champions League 19/20 |
| 4 | Wesley Sonck | Group Stage | UEFA Champions League 03/04 |
| 3 | Steven Bergwijn | Group Stage | UEFA Champions League 22/23 |
| 3 | Steven Berghuis | Group Stage | UEFA Champions League 21/22 |
| 3 | Nicolas Tagliafico | Group Stage | UEFA Champions League 18/19 |
| 3 | Donny van de Beek | Group Stage | UEFA Champions League 18/19 |
| 3 | Hakim Ziyech | Round of 16 | UEFA Champions League 18/19 |
| 3 | Lasse Schone | Group Stage | UEFA Champions League 14/15 |
| 3 | Siem De Jong | Group Stage | UEFA Champions League 12/13 |
| 3 | Tijani Babangida | Quarter-finals | UEFA Champions League 96/97 |
| 3 | Dani | Quarter-finals | UEFA Champions League 96/97 |
| 3 | Nigel De Jong | Group Stage | UEFA Champions League 05/06 |
| 3 | Yannis Anastasiou | Group Stage | UEFA Champions League 05/06 |
| 2 | Antony | Group Stage | UEFA Champions League 21/22 |
| 2 | Dusan Tadic | Group Stage | UEFA Champions League 21/22 |
| 2 | Dusan Tadic | Group Stage | UEFA Champions League 20/21 |
| 2 | Hakim Ziyech | Group Stage | UEFA Champions League 19/20 |
| 2 | Donny van de Beek | Group Stage | UEFA Champions League 19/20 |
| 2 | Noussair Mazraoui | Group Stage | UEFA Champions League 18/19 |
| 2 | David Neres | Round of 16 | UEFA Champions League 18/19 |
| 2 | Matthijs de Ligt | Quarter-finals | UEFA Champions League 18/19 |
| 2 | Davy Klaassen | Group Stage | UEFA Champions League 14/15 |
| 2 | Lasse Schone | Group Stage | UEFA Champions League 13/14 |
| 2 | Niklas Moisander | Group Stage | UEFA Champions League 12/13 |
| 2 | Miralem Sulejmani | Group Stage | UEFA Champions League 11/12 |
| 2 | Demy de Zeeuw | Group Stage | UEFA Champions League 10/11 |
| 2 | Toby Alderweireld | Group Stage | UEFA Champions League 10/11 |
| 2 | Patrick Kluivert | Final | UEFA Champions League 94/95 |
| 2 | Ronald de Boer | Semi-finals | UEFA Champions League 94/95 |
| 2 | Frank de Boer | Quarter-finals | UEFA Champions League 94/95 |
| 2 | Tarik Oulida | Group Stage | UEFA Champions League 94/95 |
| 2 | Marc Overmars | Group Stage | UEFA Champions League 95/96 |
| 2 | Patrick Kluivert | Quarter-finals | UEFA Champions League 96/97 |
| 2 | Jari Litmanen | Group Stage | UEFA Champions League 96/97 |
| 2 | Wesley Sneijder | Group Stage | UEFA Champions League 05/06 |
| 2 | Rafael van der Vaart | First Group Stage | UEFA Champions League 02/03 |
| 2 | Steven Pienaar | First Group Stage | UEFA Champions League 02/03 |
| 2 | Jari Litmanen | Second Group Stage | UEFA Champions League 02/03 |
| 1 | Steven Berghuis | Group Stage | UEFA Champions League 22/23 |
| 1 | Davy Klaassen | Group Stage | UEFA Champions League 22/23 |
| 1 | Francisco Conceicao | Group Stage | UEFA Champions League 22/23 |
| 1 | Edson Alvarez | Group Stage | UEFA Champions League 22/23 |
| 1 | Daley Blind | Group Stage | UEFA Champions League 21/22 |
| 1 | David Neres | Group Stage | UEFA Champions League 21/22 |
| 1 | Davy Klaassen | Group Stage | UEFA Champions League 21/22 |
| 1 | Noussair Mazraoui | Group Stage | UEFA Champions League 20/21 |
| 1 | Lassina Traore | Group Stage | UEFA Champions League 20/21 |
| 1 | Ryan Gravenberch | Group Stage | UEFA Champions League 20/21 |
| 1 | Antony | Group Stage | UEFA Champions League 20/21 |
| 1 | David Neres | Group Stage | UEFA Champions League 20/21 |
| 1 | Edson Alvarez | Group Stage | UEFA Champions League 19/20 |
| 1 | Nicolas Tagliafico | Group Stage | UEFA Champions League 19/20 |
| 1 | Lasse Schone | Round of 16 | UEFA Champions League 18/19 |
