| 9 | Simone Inzaghi | Quarter-finals | UEFA Champions League 99/00 |
| 5 | Ciro Immobile | Group Stage | UEFA Champions League 20/21 |
| 5 | Claudio Lopez | First Group Stage | UEFA Champions League 00/01 |
| 4 | Ciro Immobile | Group Section | UEFA Champions League 23/24 |
| 4 | Goran Pandev | Group Stage | UEFA Champions League 07/08 |
| 4 | Marcelo Salas | Quarter-finals | UEFA Champions League 99/00 |
| 3 | Joaquin Correa | Group Stage | UEFA Champions League 20/21 |
| 3 | Simone Inzaghi | Group Stage | UEFA Champions League 03/04 |
| 3 | Sinesa Mihajlovic | First Group Stage | UEFA Champions League 99/00 |
| 3 | Pavel Nedved | First Group Stage | UEFA Champions League 00/01 |
| 3 | Simone Inzaghi | First Group Stage | UEFA Champions League 00/01 |
| 2 | Marco Parolo | Group Stage | UEFA Champions League 20/21 |
| 2 | Pedro Rodriguez | Group Section | UEFA Champions League 23/24 |
| 2 | Tommaso Rocchi | Group Stage | UEFA Champions League 07/08 |
| 2 | Juan Sebastian Veron | Quarter-finals | UEFA Champions League 99/00 |
| 2 | Sergio Conceicao | First Group Stage | UEFA Champions League 99/00 |
| 2 | Dejan Stankovic | First Group Stage | UEFA Champions League 99/00 |
| 2 | Hernan Crespo | Second Group Stage | UEFA Champions League 00/01 |
| 2 | Sinesa Mihajlovic | Second Group Stage | UEFA Champions League 00/01 |
| 2 | Fabrizio Ravanelli | First Group Stage | UEFA Champions League 00/01 |
| 1 | Jean Daniel Akpa Akpro | Group Stage | UEFA Champions League 20/21 |
| 1 | Felipe Caicedo | Group Stage | UEFA Champions League 20/21 |
| 1 | Ivan Provedel | Group Section | UEFA Champions League 23/24 |
| 1 | Matias Vecino | Group Section | UEFA Champions League 23/24 |
| 1 | Christian Manfredini | Group Stage | UEFA Champions League 07/08 |
| 1 | Luciano Zauri | Group Stage | UEFA Champions League 07/08 |
| 1 | Roberto Muzzi | Group Stage | UEFA Champions League 03/04 |
| 1 | Jaap Stam | Group Stage | UEFA Champions League 03/04 |
| 1 | Stefano Fiore | Group Stage | UEFA Champions League 03/04 |
| 1 | Pavel Nedved | First Group Stage | UEFA Champions League 99/00 |
| 1 | Paulo Negro | First Group Stage | UEFA Champions League 99/00 |
| 1 | Alen Boksic | Second Group Stage | UEFA Champions League 99/00 |
| 1 | Claudio Lopez | First Group Stage | UEFA Champions League 01/02 |
| 1 | Stefano Fiore | First Group Stage | UEFA Champions League 01/02 |
| 1 | Dejan Stankovic | First Group Stage | UEFA Champions League 01/02 |
| 1 | Fernando Couto | First Group Stage | UEFA Champions League 01/02 |
| 1 | Juan Sebastian Veron | First Group Stage | UEFA Champions League 00/01 |
| 1 | Roberto Baronio | Second Group Stage | UEFA Champions League 00/01 |
| 1 | Giuseppe Favalli | First Group Stage | UEFA Champions League 00/01 |
| 1 | Diego Simeone | First Group Stage | UEFA Champions League 00/01 |
| 1 | Guerino Gottardi | Second Group Stage | UEFA Champions League 00/01 |
