| 10 | Alessandro Del Piero | Semi-finals | UEFA Champions League 97/98 |
| 8 | David Trezeguet | First Group Stage | UEFA Champions League 01/02 |
| 7 | Carlos Tevez | Group Stage | UEFA Champions League 14/15 |
| 6 | Alvaro Morata | Group Stage | UEFA Champions League 20/21 |
| 6 | Cristiano Ronaldo | Group Stage | UEFA Champions League 18/19 |
| 6 | Alessandro Del Piero | Group Stage | UEFA Champions League 95/96 |
| 6 | Filippo Inzaghi | Semi-finals | UEFA Champions League 98/99 |
| 6 | Filippo Inzaghi | Quarter-finals | UEFA Champions League 97/98 |
| 6 | David Trezeguet | Group Stage | UEFA Champions League 05/06 |
| 5 | Paulo Dybala | Group Stage | UEFA Champions League 18/19 |
| 5 | Gonzalo Higuain | Group Stage | UEFA Champions League 17/18 |
| 5 | Gonzalo Higuain | Group Stage | UEFA Champions League 16/17 |
| 5 | Alvaro Morata | Round of 16 | UEFA Champions League 14/15 |
| 5 | Arturo Vidal | Group Stage | UEFA Champions League 13/14 |
| 5 | Alessandro Del Piero | Group Stage | UEFA Champions League 08/09 |
| 5 | Fabrizio Ravanelli | Group Stage | UEFA Champions League 95/96 |
| 5 | Pavel Nedved | First Group Stage | UEFA Champions League 02/03 |
| 5 | Alessandro Del Piero | First Group Stage | UEFA Champions League 02/03 |
| 5 | Filippo Inzaghi | First Group Stage | UEFA Champions League 00/01 |
| 4 | Cristiano Ronaldo | Group Stage | UEFA Champions League 20/21 |
| 4 | Cristiano Ronaldo | Group Stage | UEFA Champions League 19/20 |
| 4 | Mario Mandzukic | Group Stage | UEFA Champions League 17/18 |
| 4 | Paulo Dybala | Group Stage | UEFA Champions League 16/17 |
| 4 | Fabio Quagliarella | Group Stage | UEFA Champions League 12/13 |
| 4 | Nicola Amoruso | Quarter-finals | UEFA Champions League 96/97 |
| 4 | Alen Boksic | Group Stage | UEFA Champions League 96/97 |
| 4 | Christian Vieri | Quarter-finals | UEFA Champions League 96/97 |
| 4 | Alessandro Del Piero | Group Stage | UEFA Champions League 96/97 |
| 4 | David Trezeguet | Group Stage | UEFA Champions League 03/04 |
| 4 | David Trezeguet | Second Group Stage | UEFA Champions League 02/03 |
| 4 | Marco Di Vaio | First Group Stage | UEFA Champions League 02/03 |
| 4 | Alessandro Del Piero | First Group Stage | UEFA Champions League 01/02 |
| 3 | Paulo Dybala | Group Stage | UEFA Champions League 21/22 |
| 3 | Paulo Dybala | Group Stage | UEFA Champions League 19/20 |
| 3 | Dani Alves | Group Stage | UEFA Champions League 16/17 |
| 3 | Mario Mandzukic | Group Stage | UEFA Champions League 16/17 |
| 3 | Arturo Vidal | Group Stage | UEFA Champions League 12/13 |
| 3 | Vincenzo Iaquinta | Group Stage | UEFA Champions League 08/09 |
| 3 | Antonio Conte | Semi-finals | UEFA Champions League 98/99 |
| 3 | Zinedine Zidane | Semi-finals | UEFA Champions League 97/98 |
| 3 | Alessandro Del Piero | Group Stage | UEFA Champions League 05/06 |
| 3 | Zlatan Ibrahimovic | Group Stage | UEFA Champions League 05/06 |
| 3 | Alessandro Del Piero | Group Stage | UEFA Champions League 03/04 |
| 3 | Marco Di Vaio | Group Stage | UEFA Champions League 03/04 |
| 2 | Weston McKennie | Group Stage | UEFA Champions League 22/23 |
| 2 | Arkadiusz Milik | Group Stage | UEFA Champions League 22/23 |
| 2 | Adrien Rabiot | Group Stage | UEFA Champions League 22/23 |
| 2 | Federico Chiesa | Group Stage | UEFA Champions League 21/22 |
| 2 | Alvaro Morata | Group Stage | UEFA Champions League 21/22 |
| 2 | Federico Chiesa | Group Stage | UEFA Champions League 20/21 |
| 2 | Gonzalo Higuain | Group Stage | UEFA Champions League 19/20 |
| 2 | Miralem Pjanic | Group Stage | UEFA Champions League 18/19 |
| 2 | Mario Mandzukic | Group Stage | UEFA Champions League 15/16 |
| 2 | Alvaro Morata | Group Stage | UEFA Champions League 15/16 |
| 2 | Fabio Quagliarella | Group Stage | UEFA Champions League 13/14 |
| 2 | Fernando Llorente | Group Stage | UEFA Champions League 13/14 |
| 2 | Alessandro Matri | Round of 16 | UEFA Champions League 12/13 |
| 2 | Mirko Vucinic | Group Stage | UEFA Champions League 12/13 |
| 2 | Claudio Marchisio | Group Stage | UEFA Champions League 12/13 |
| 2 | Sebastian Giovinco | Group Stage | UEFA Champions League 12/13 |
