| 12 | Ruud van Nistelrooy | First Group Stage | UEFA Champions League 02/03 |
| 10 | Ruud van Nistelrooy | First Group Stage | UEFA Champions League 01/02 |
| 8 | Dwight Yorke | Semi-finals | UEFA Champions League 98/99 |
| 8 | Cristiano Ronaldo | Group Stage | UEFA Champions League 07/08 |
| 8 | Ruud van Nistelrooy | Group Stage | UEFA Champions League 04/05 |
| 7 | Ole-Gunnar Solskjaer | First Group Stage | UEFA Champions League 01/02 |
| 6 | Cristiano Ronaldo | Group Stage | UEFA Champions League 21/22 |
| 6 | Marcus Rashford | Group Stage | UEFA Champions League 20/21 |
| 6 | Roy Keane | Second Group Stage | UEFA Champions League 99/00 |
| 6 | Paul Scholes | First Group Stage | UEFA Champions League 00/01 |
| 5 | Romelu Lukaku | Group Stage | UEFA Champions League 17/18 |
| 5 | Rasmus Hojlund | Group Section | UEFA Champions League 23/24 |
| 5 | Wayne Rooney | Round of 16 | UEFA Champions League 09/10 |
| 5 | Andrew Cole | Group Stage | UEFA Champions League 97/98 |
| 5 | Ryan Giggs | First Group Stage | UEFA Champions League 02/03 |
| 5 | David Beckham | First Group Stage | UEFA Champions League 01/02 |
| 5 | Teddy Sheringham | First Group Stage | UEFA Champions League 00/01 |
| 4 | Bruno Fernandes | Group Stage | UEFA Champions League 20/21 |
| 4 | Robin van Persie | Group Stage | UEFA Champions League 13/14 |
| 4 | Wayne Rooney | Group Stage | UEFA Champions League 10/11 |
| 4 | Javier Hernandez | Group Stage | UEFA Champions League 10/11 |
| 4 | Michael Owen | Group Stage | UEFA Champions League 09/10 |
| 4 | Dimitar Berbatov | Group Stage | UEFA Champions League 08/09 |
| 4 | Wayne Rooney | Group Stage | UEFA Champions League 08/09 |
| 4 | Cristiano Ronaldo | Round of 16 | UEFA Champions League 08/09 |
| 4 | Ryan Giggs | Semi-finals | UEFA Champions League 98/99 |
| 4 | Paul Scholes | Quarter-finals | UEFA Champions League 98/99 |
| 4 | Andrew Cole | Semi-finals | UEFA Champions League 98/99 |
| 4 | Carlos Tevez | Group Stage | UEFA Champions League 07/08 |
| 4 | Wayne Rooney | Group Stage | UEFA Champions League 07/08 |
| 4 | Wayne Rooney | Quarter-finals | UEFA Champions League 06/07 |
| 4 | Louis Saha | Group Stage | UEFA Champions League 06/07 |
| 4 | Ruud van Nistelrooy | Group Stage | UEFA Champions League 03/04 |
| 4 | Juan Sebastian Veron | First Group Stage | UEFA Champions League 02/03 |
| 4 | Andrew Cole | First Group Stage | UEFA Champions League 00/01 |
| 3 | Marcus Rashford | Group Stage | UEFA Champions League 17/18 |
| 3 | Javier Hernandez | Group Stage | UEFA Champions League 12/13 |
| 3 | Robin van Persie | Group Stage | UEFA Champions League 12/13 |
| 3 | Anderson | Group Stage | UEFA Champions League 10/11 |
| 3 | Paul Scholes | Group Stage | UEFA Champions League 09/10 |
| 3 | Roy Keane | Semi-finals | UEFA Champions League 98/99 |
| 3 | Eric Cantona | Quarter-finals | UEFA Champions League 96/97 |
| 3 | Cristiano Ronaldo | Semi-finals | UEFA Champions League 06/07 |
| 3 | Wayne Rooney | Group Stage | UEFA Champions League 04/05 |
| 3 | Ole-Gunnar Solskjaer | First Group Stage | UEFA Champions League 02/03 |
| 3 | Paul Scholes | Quarter-finals | UEFA Champions League 99/00 |
| 3 | Andrew Cole | Second Group Stage | UEFA Champions League 99/00 |
| 3 | Ole-Gunnar Solskjaer | Second Group Stage | UEFA Champions League 99/00 |
| 2 | Anthony Martial | Group Stage | UEFA Champions League 20/21 |
| 2 | Paul Pogba | Group Stage | UEFA Champions League 18/19 |
| 2 | Romelu Lukaku | Round of 16 | UEFA Champions League 18/19 |
| 2 | Anthony Martial | Group Stage | UEFA Champions League 15/16 |
| 2 | Casemiro | Group Section | UEFA Champions League 23/24 |
| 2 | Bruno Fernandes | Group Section | UEFA Champions League 23/24 |
| 2 | Wayne Rooney | Group Stage | UEFA Champions League 13/14 |
| 2 | Luis Antonio Valencia | Group Stage | UEFA Champions League 13/14 |
| 2 | Danny Welbeck | Group Stage | UEFA Champions League 11/12 |
| 2 | Wayne Rooney | Group Stage | UEFA Champions League 11/12 |
| 2 | Luis Antonio Valencia | Group Stage | UEFA Champions League 09/10 |
| 2 | Nani | Quarter-finals | UEFA Champions League 09/10 |
