| 5 | Jorge Costa | Group Stage | UEFA Champions League 03/04 |
| 5 | Aloisio | Quarter-finals | UEFA Champions League 99/00 |
| 4 | Ivan Marcano | Group Stage | UEFA Champions League 14/15 |
| 4 | Jorge Costa | Group Stage | UEFA Champions League 04/05 |
| 4 | Costinha | Group Stage | UEFA Champions League 03/04 |
| 4 | Deco | Group Stage | UEFA Champions League 03/04 |
| 4 | Jorge Costa | Quarter-finals | UEFA Champions League 99/00 |
| 4 | Costinha | First Group Stage | UEFA Champions League 01/02 |
| 3 | Joao Mario | Group Stage | UEFA Champions League 22/23 |
| 3 | Otavio | Group Stage | UEFA Champions League 22/23 |
| 3 | Pepe (11) | Group Stage | UEFA Champions League 22/23 |
| 3 | David Carmo | Group Stage | UEFA Champions League 22/23 |
| 3 | Mateus Uribe | Group Stage | UEFA Champions League 22/23 |
| 3 | Mateus Uribe | Group Stage | UEFA Champions League 21/22 |
| 3 | Sergio Oliveira | Group Stage | UEFA Champions League 20/21 |
| 3 | Jesus Manuel Corona | Group Stage | UEFA Champions League 18/19 |
| 3 | Hector Herrera | Group Stage | UEFA Champions League 18/19 |
| 3 | Sergio Oliveira | Group Stage | UEFA Champions League 17/18 |
| 3 | Andre Andre | Group Stage | UEFA Champions League 17/18 |
| 3 | Danilo Pereira | Group Stage | UEFA Champions League 15/16 |
| 3 | Maxi Pereira | Group Stage | UEFA Champions League 15/16 |
| 3 | David Carmo | Group Section | UEFA Champions League 23/24 |
| 3 | Pepe | Group Section | UEFA Champions League 23/24 |
| 3 | Danilo | Group Stage | UEFA Champions League 14/15 |
| 3 | Alex Sandro | Group Stage | UEFA Champions League 14/15 |
| 3 | Nicolas Otamendi | Group Stage | UEFA Champions League 11/12 |
| 3 | Alvaro Pereira | Group Stage | UEFA Champions League 09/10 |
| 3 | Fernando | Group Stage | UEFA Champions League 09/10 |
| 3 | Emil Kostadinov | Group Stage | UEFA Champions League 93/94 |
| 3 | Paulinho Santos | Group Stage | UEFA Champions League 98/99 |
| 3 | Paulinho Santos | Quarter-finals | UEFA Champions League 96/97 |
| 3 | Jose Bosingwa | Group Stage | UEFA Champions League 05/06 |
| 3 | Carlos Alberto | Semi-finals | UEFA Champions League 03/04 |
| 3 | Maniche | Group Stage | UEFA Champions League 03/04 |
| 3 | Paulinho Santos | Quarter-finals | UEFA Champions League 99/00 |
| 3 | Deco | Quarter-finals | UEFA Champions League 99/00 |
| 3 | Mario Silva | First Group Stage | UEFA Champions League 01/02 |
| 2 | Chancel Mbemba | Group Stage | UEFA Champions League 21/22 |
| 2 | Vitinha | Group Stage | UEFA Champions League 21/22 |
| 2 | Pepe | Group Stage | UEFA Champions League 20/21 |
| 2 | Luis Diaz | Group Stage | UEFA Champions League 20/21 |
| 2 | Jesus Manuel Corona | Group Stage | UEFA Champions League 20/21 |
| 2 | Marko Grujic | Group Stage | UEFA Champions League 20/21 |
| 2 | Eder Militao | Group Stage | UEFA Champions League 18/19 |
| 2 | Felipe | Group Stage | UEFA Champions League 18/19 |
| 2 | Otavio | Group Stage | UEFA Champions League 18/19 |
| 2 | Danilo Pereira | Group Stage | UEFA Champions League 18/19 |
| 2 | Pepe | Round of 16 | UEFA Champions League 18/19 |
| 2 | Danilo Pereira | Group Stage | UEFA Champions League 17/18 |
| 2 | Andre Silva | Group Stage | UEFA Champions League 16/17 |
| 2 | Ivan Marcano | Group Stage | UEFA Champions League 16/17 |
| 2 | Miguel Layun | Group Stage | UEFA Champions League 16/17 |
| 2 | Felipe | Group Stage | UEFA Champions League 16/17 |
| 2 | Hector Herrera | Group Stage | UEFA Champions League 16/17 |
| 2 | Bruno Martins Indi | Group Stage | UEFA Champions League 15/16 |
| 2 | Joao Mario | Group Section | UEFA Champions League 23/24 |
| 2 | Francisco Conceicao | Group Section | UEFA Champions League 23/24 |
| 2 | Fabio Cardoso | Group Section | UEFA Champions League 23/24 |
| 2 | Oliver Torres | Group Stage | UEFA Champions League 14/15 |
| 2 | Maicon | Group Stage | UEFA Champions League 14/15 |
