| # | Players | Clubs | Nationality | GC | More |
|---|---|---|---|---|---|
| 1 | Brian Jensen | Burnley | Denmark | 80 | |
| 2 | Jussi Jaaskelainen | Bolton Wanderers | Finland | 67 | |
| 3 | Robert Green | West Ham United | England | 64 | |
| 4 | Christopher Kirkland | Wigan Athletic | England | 62 | |
| 5 | Boaz Myhill | Hull City | Wales | 58 | |
| 6 | Paul Robinson | Blackburn Rovers | England | 55 | |
| 7 | Tim Howard | Everton | United States | 53 | |
| 8 | Mark Schwarzer | Fulham | Australia | 46 | |
| 9 | David James | Portsmouth | England | 46 | |
| 10 | Joe Hart | Birmingham City | England | 43 | |
| 11 | Thomas Sorensen | Stoke City | Denmark | 42 | |
| 12 | Shay Given | Manchester City | Republic of Ireland | 41 | |
| 13 | Brad Friedel | Aston Villa | United States | 41 | |
| 14 | Pepe Reina | Liverpool | Spain | 38 | |
| 15 | Manuel Almunia | Arsenal | Spain | 36 | |
| 16 | Craig Gordon | Sunderland | Scotland | 34 | |
| 17 | Marcus Hahnemann | Wolverhampton Wanderers | United States | 32 | |
| 18 | Petr Cech | Chelsea | Czech Republic | 30 | |
| 19 | Wayne Hennessey | Wolverhampton Wanderers | Wales | 27 | |
| 20 | Heurelho Gomes | Tottenham Hotspur | Brazil | 27 |
GC = Goals conceded