| MD | Players | Nationality | DOB | A(D) |
|---|---|---|---|---|
| 22-Feb-2018 | Christian Maggio | Italy | 11-Feb-1982 | 36(11) |
| 21-Feb-2013 | Morgan De Sanctis | Italy | 26-Mar-1977 | 35(333) |
| 14-May-2015 | Mariano Andujar | Argentina | 30-Jun-1979 | 35(319) |
| 22-Feb-2018 | Pepe Reina | Spain | 31-Aug-1982 | 35(176) |
| 16-Sep-2010 | Cristiano Lucarelli | Italy | 04-Oct-1975 | 34(348) |
| 22-Nov-2012 | Salvatore Aronica | Italy | 20-Jan-1978 | 34(307) |
| 24-Feb-2022 | Dries Mertens | Belgium | 06-May-1987 | 34(295) |
| 13-Mar-2014 | Anthony Reveillere | France | 10-Nov-1979 | 34(124) |
| 02-Dec-2010 | Gianluca Grava | Italy | 07-Mar-1977 | 33(270) |
| 16-Sep-2021 | David Ospina | Colombia | 31-Aug-1988 | 33(16) |
| 23-Apr-2015 | Giandomencio Mesto | Italy | 25-May-1982 | 32(333) |
| 22-Feb-2018 | Raul Albiol | Spain | 04-Sep-1985 | 32(171) |
| 06-Dec-2012 | Hugo Campagnaro | Argentina | 27-Jun-1980 | 32(162) |
| 18-Apr-2019 | Jose Callejon | Spain | 11-Feb-1987 | 32(66) |
| 21-Feb-2013 | Paolo Cannavaro | Italy | 26-Jun-1981 | 31(241) |
| 24-Feb-2011 | Giuseppe Mascara | Italy | 22-Aug-1979 | 31(186) |
| 21-Feb-2013 | Alessandro Gamberini | Italy | 27-Aug-1981 | 31(178) |
| 06-Dec-2012 | Andrea Dossena | Italy | 11-Sep-1981 | 31(86) |
| 21-Feb-2013 | Emanuele Calaio | Italy | 08-Jan-1982 | 31(44) |
| 24-Feb-2022 | Faouzi Ghoulam | Algeria | 01-Feb-1991 | 31(23) |
| 24-Feb-2011 | Emilson Cribari | Brazil | 06-Mar-1980 | 30(355) |
| 14-May-2015 | Gokhan Inler | Switzerland | 27-Jun-1984 | 30(321) |
| 07-May-2015 | Walter Gargano | Uruguay | 27-Jul-1984 | 30(284) |
| 24-Feb-2022 | Mario Rui | Portugal | 27-May-1991 | 30(274) |
| 24-Feb-2022 | Lorenzo Insigne | Italy | 04-Jun-1991 | 30(266) |
| 17-Feb-2022 | Juan | Brazil | 10-Jun-1991 | 30(253) |
| 24-Feb-2022 | Kalidou Koulibaly | Senegal | 20-Jun-1991 | 30(250) |
| 20-Mar-2014 | Goran Pandev | Macedonia | 27-Jul-1983 | 30(237) |
| 22-Feb-2018 | Marek Hamsik | Slovakia | 27-Jul-1987 | 30(211) |
| 17-Feb-2022 | Kevin Malcuit | France | 31-Jul-1991 | 30(202) |
| 09-Dec-2021 | Kostas Manolas | Greece | 14-Jun-1991 | 30(179) |
| 24-Feb-2022 | Diego Demme | Germany | 21-Nov-1991 | 30(96) |
| 25-Feb-2016 | Mirko Valdifiori | Italy | 21-Apr-1986 | 29(310) |
| 21-Feb-2013 | Marco Donadel | Italy | 21-Apr-1983 | 29(307) |
| 14-May-2015 | Miguel Britos | Uruguay | 17-Jul-1985 | 29(301) |
| 06-Dec-2012 | Antonio Rosati | Italy | 26-Mar-1983 | 29(256) |
| 18-Apr-2019 | Vlad Chiriches | Romania | 14-Nov-1989 | 29(155) |
| 19-Mar-2015 | Camilo Zuniga | Colombia | 14-Dec-1985 | 29(95) |
| 25-Feb-2021 | Nikola Maksimovic | Serbia | 25-Nov-1991 | 29(93) |
| 20-Mar-2014 | Valon Behrami | Switzerland | 19-Apr-1985 | 28(335) |
| 25-Feb-2016 | Ivan Strinic | Croatia | 17-Jul-1987 | 28(223) |
| 23-Oct-2014 | Michu | Spain | 21-Mar-1986 | 28(216) |
| 14-May-2015 | Henrique | Brazil | 14-Oct-1986 | 28(212) |
| 24-Feb-2022 | Giovanni Di Lorenzo | Italy | 04-Aug-1993 | 28(204) |
| 24-Feb-2011 | Michele Pazienza | Italy | 05-Aug-1982 | 28(203) |
| 18-Apr-2019 | Allan | Brazil | 08-Jan-1991 | 28(100) |
| 21-Oct-2021 | Matteo Politano | Italy | 03-Aug-1993 | 28(79) |
| 25-Feb-2016 | Gonzalo Higuain | Argentina | 10-Dec-1987 | 28(77) |
| 22-Feb-2018 | Lorenzo Tonelli | Italy | 28-Jan-1990 | 28(25) |
| 24-Feb-2022 | Amir Rrahmani | Kosovo | 24-Feb-1994 | 28(0) |
MD = Match date,
DOB = Date Of Birth,
A(D) = Age(Days).