| 10 | Kaka | Group Stage | UEFA Champions League 06/07 |
| 10 | Filippo Inzaghi | First Group Stage | UEFA Champions League 02/03 |
| 9 | Andriy Shevchenko | Group Stage | UEFA Champions League 05/06 |
| 6 | Andriy Shevchenko | Group Stage | UEFA Champions League 04/05 |
| 6 | Hernan Crespo | Group Stage | UEFA Champions League 04/05 |
| 5 | Olivier Giroud | Group Stage | UEFA Champions League 22/23 |
| 5 | Zlatan Ibrahimovic | Group Stage | UEFA Champions League 11/12 |
| 5 | Kaka | Group Stage | UEFA Champions League 05/06 |
| 5 | Andriy Shevchenko | First Group Stage | UEFA Champions League 00/01 |
| 4 | Zlatan Ibrahimovic | Group Stage | UEFA Champions League 10/11 |
| 4 | Marco van Basten | Group Stage | UEFA Champions League 92/93 |
| 4 | Daniele Massaro | Final | UEFA Champions League 93/94 |
| 4 | Marco Simone | Quarter-finals | UEFA Champions League 94/95 |
| 4 | Marco Simone | Group Stage | UEFA Champions League 96/97 |
| 4 | Filippo Inzaghi | Group Stage | UEFA Champions League 07/08 |
| 4 | Filippo Inzaghi | Group Stage | UEFA Champions League 06/07 |
| 4 | Filippo Inzaghi | Round of 16 | UEFA Champions League 05/06 |
| 4 | Andriy Shevchenko | Group Stage | UEFA Champions League 03/04 |
| 4 | Kaka | Group Stage | UEFA Champions League 03/04 |
| 4 | Andriy Shevchenko | First Group Stage | UEFA Champions League 02/03 |
| 4 | Jose Mari | First Group Stage | UEFA Champions League 00/01 |
| 3 | Kevin-Prince Boateng | Group Stage | UEFA Champions League 11/12 |
| 3 | Robinho | Group Stage | UEFA Champions League 11/12 |
| 3 | Ronaldinho Gaucho | Group Stage | UEFA Champions League 09/10 |
| 3 | Marco Simone | Group Stage | UEFA Champions League 92/93 |
| 3 | Dejan Savicevic | Final | UEFA Champions League 93/94 |
| 3 | George Weah | Group Stage | UEFA Champions League 96/97 |
| 3 | Jon Dahl Tomasson | First Group Stage | UEFA Champions League 02/03 |
| 2 | Alexis Saelemaekers | Group Stage | UEFA Champions League 22/23 |
| 2 | Samuel Chukwueze | Group Section | UEFA Champions League 23/24 |
| 2 | Mario Balotelli | Group Stage | UEFA Champions League 13/14 |
| 2 | Kaka | Group Stage | UEFA Champions League 13/14 |
| 2 | Stephan El Shaaraway | Group Stage | UEFA Champions League 12/13 |
| 2 | Alexandre Pato | Group Stage | UEFA Champions League 12/13 |
| 2 | Alexandre Pato | Group Stage | UEFA Champions League 11/12 |
| 2 | Filippo Inzaghi | Group Stage | UEFA Champions League 10/11 |
| 2 | Filippo Inzaghi | Group Stage | UEFA Champions League 09/10 |
| 2 | Alexandre Pato | Group Stage | UEFA Champions League 09/10 |
| 2 | Marcel Desailly | Final | UEFA Champions League 93/94 |
| 2 | Christian Panucci | Group Stage | UEFA Champions League 94/95 |
| 2 | Dejan Savicevic | Semi-finals | UEFA Champions League 94/95 |
| 2 | Clarence Seedorf | Group Stage | UEFA Champions League 07/08 |
| 2 | Andrea Pirlo | Group Stage | UEFA Champions League 07/08 |
| 2 | Kaka | Group Stage | UEFA Champions League 07/08 |
| 2 | Alberto Gilardino | Group Stage | UEFA Champions League 07/08 |
| 2 | Alberto Gilardino | Group Stage | UEFA Champions League 06/07 |
| 2 | Clarence Seedorf | Semi-finals | UEFA Champions League 06/07 |
| 2 | Kaka | Group Stage | UEFA Champions League 04/05 |
| 2 | Filippo Inzaghi | Group Stage | UEFA Champions League 03/04 |
| 2 | Rivaldo | Second Group Stage | UEFA Champions League 02/03 |
| 2 | Oliver Bierhoff | First Group Stage | UEFA Champions League 99/00 |
| 2 | Oliver Bierhoff | First Group Stage | UEFA Champions League 00/01 |
| 2 | Francesco Coco | First Group Stage | UEFA Champions League 00/01 |
| 2 | Demetrio Albertini | First Group Stage | UEFA Champions League 00/01 |
| 1 | Matteo Gabbia | Group Stage | UEFA Champions League 22/23 |
| 1 | Brahim Diaz | Round of 16 | UEFA Champions League 22/23 |
| 1 | Rafael Leao | Group Stage | UEFA Champions League 22/23 |
| 1 | Ismael Bennacer | Quarter-finals | UEFA Champions League 22/23 |
| 1 | Rade Krunic | Group Stage | UEFA Champions League 22/23 |
| 1 | Tommaso Pobego | Group Stage | UEFA Champions League 22/23 |
