| 9 | Hernan Crespo | First Group Stage | UEFA Champions League 02/03 |
| 8 | Samuel Eto'o | Group Stage | UEFA Champions League 10/11 |
| 7 | Adriano | Group Stage | UEFA Champions League 04/05 |
| 6 | Diego Milito | Group Stage | UEFA Champions League 09/10 |
| 5 | Lautaro Martinez | Group Stage | UEFA Champions League 19/20 |
| 5 | Zlatan Ibrahimovic | Group Stage | UEFA Champions League 07/08 |
| 5 | Adriano | Group Stage | UEFA Champions League 05/06 |
| 5 | Obafemi Martins | Group Stage | UEFA Champions League 04/05 |
| 4 | Edin Dzeko | Group Stage | UEFA Champions League 22/23 |
| 4 | Romelu Lukaku | Group Stage | UEFA Champions League 20/21 |
| 4 | Mauro Icardi | Group Stage | UEFA Champions League 18/19 |
| 4 | Julio Cruz | Group Stage | UEFA Champions League 05/06 |
| 3 | Lautaro Martinez | Group Stage | UEFA Champions League 22/23 |
| 3 | Romelu Lukaku | Group Stage | UEFA Champions League 22/23 |
| 3 | Nicolo Barella | Group Stage | UEFA Champions League 22/23 |
| 3 | Edin Dzeko | Group Stage | UEFA Champions League 21/22 |
| 3 | Giampaolo Pazzini | Group Stage | UEFA Champions League 11/12 |
| 3 | Wesley Sneijder | Group Stage | UEFA Champions League 10/11 |
| 3 | Wesley Sneijder | Group Stage | UEFA Champions League 09/10 |
| 3 | Roberto Baggio | Group Stage | UEFA Champions League 98/99 |
| 3 | Julio Cruz | Group Stage | UEFA Champions League 06/07 |
| 3 | Christian Vieri | Second Group Stage | UEFA Champions League 02/03 |
| 2 | Henrikh Mkhitaryan | Group Stage | UEFA Champions League 22/23 |
| 2 | Romelu Lukaku | Group Stage | UEFA Champions League 19/20 |
| 2 | Lautaro Martinez | Group Section | UEFA Champions League 23/24 |
| 2 | Marko Arnautovic | Group Section | UEFA Champions League 23/24 |
| 2 | Alexis Sanchez | Group Section | UEFA Champions League 23/24 |
| 2 | Diego Milito | Group Stage | UEFA Champions League 11/12 |
| 2 | Dejan Stankovic | Group Stage | UEFA Champions League 10/11 |
| 2 | Dejan Stankovic | Group Stage | UEFA Champions League 09/10 |
| 2 | Samuel Eto'o | Group Stage | UEFA Champions League 09/10 |
| 2 | Adriano | Group Stage | UEFA Champions League 08/09 |
| 2 | Nicola Ventola | Quarter-finals | UEFA Champions League 98/99 |
| 2 | Esteban Cambiasso | Group Stage | UEFA Champions League 07/08 |
| 2 | Julio Cruz | Group Stage | UEFA Champions League 07/08 |
| 2 | Dejan Stankovic | Round of 16 | UEFA Champions League 05/06 |
| 2 | Dejan Stankovic | Group Stage | UEFA Champions League 04/05 |
| 2 | Julio Cruz | Group Stage | UEFA Champions League 04/05 |
| 2 | Daniele Adani | Group Stage | UEFA Champions League 03/04 |
| 2 | Christian Vieri | Group Stage | UEFA Champions League 03/04 |
| 2 | Obafemi Martins | Second Group Stage | UEFA Champions League 02/03 |
| 2 | Luigi Di Biagio | Second Group Stage | UEFA Champions League 02/03 |
| 2 | Alvaro Recoba | First Group Stage | UEFA Champions League 02/03 |
| 1 | Denzel Dumfries | Group Stage | UEFA Champions League 22/23 |
| 1 | Hakan Calhanoglu | Group Stage | UEFA Champions League 22/23 |
| 1 | Robin Gosens | Group Stage | UEFA Champions League 22/23 |
| 1 | Joaquin Correa | Quarter-finals | UEFA Champions League 22/23 |
| 1 | Stefan de Vrij | Group Stage | UEFA Champions League 21/22 |
| 1 | Milan Skriniar | Group Stage | UEFA Champions League 21/22 |
| 1 | Alexis Sanchez | Group Stage | UEFA Champions League 21/22 |
| 1 | Arturo Vidal | Group Stage | UEFA Champions League 21/22 |
| 1 | Lautaro Martinez | Round of 16 | UEFA Champions League 21/22 |
| 1 | Marcelo Brozovic | Group Stage | UEFA Champions League 21/22 |
| 1 | Ivan Perisic | Group Stage | UEFA Champions League 20/21 |
| 1 | Lautaro Martinez | Group Stage | UEFA Champions League 20/21 |
| 1 | Matteo Darmian | Group Stage | UEFA Champions League 20/21 |
| 1 | Antonio Candreva | Group Stage | UEFA Champions League 19/20 |
| 1 | Matias Vecino | Group Stage | UEFA Champions League 19/20 |
| 1 | Nicolo Barella | Group Stage | UEFA Champions League 19/20 |
| 1 | Matias Vecino | Group Stage | UEFA Champions League 18/19 |
