| 5 | Giuseppe Pancaro | Quarter-finals | UEFA Champions League 99/00 |
| 4 | Sinesa Mihajlovic | First Group Stage | UEFA Champions League 99/00 |
| 4 | Matias Almeyda | Quarter-finals | UEFA Champions League 99/00 |
| 4 | Dejan Stankovic | First Group Stage | UEFA Champions League 99/00 |
| 4 | Roberto Baronio | First Group Stage | UEFA Champions League 00/01 |
| 3 | Matias Vecino | Group Section | UEFA Champions League 23/24 |
| 3 | Nicolo Rovella | Group Section | UEFA Champions League 23/24 |
| 3 | Juan Sebastian Veron | First Group Stage | UEFA Champions League 00/01 |
| 3 | Alessandro Nesta | First Group Stage | UEFA Champions League 00/01 |
| 2 | Luis Alberto | Group Stage | UEFA Champions League 20/21 |
| 2 | Wesley Hoedt | Group Stage | UEFA Champions League 20/21 |
| 2 | Joaquin Correa | Round of 16 | UEFA Champions League 20/21 |
| 2 | Sergej Milinkovic-Savic | Group Stage | UEFA Champions League 20/21 |
| 2 | Jean Daniel Akpa Akpro | Group Stage | UEFA Champions League 20/21 |
| 2 | Franciesco Acerbi | Group Stage | UEFA Champions League 20/21 |
| 2 | Adam Marusic | Group Stage | UEFA Champions League 20/21 |
| 2 | Matteo Guendouzi | Group Section | UEFA Champions League 23/24 |
| 2 | Patric | Group Section | UEFA Champions League 23/24 |
| 2 | Valentin Castellanos | Group Section | UEFA Champions League 23/24 |
| 2 | Alessio Romagnoli | Group Section | UEFA Champions League 23/24 |
| 2 | Pedro Rodriguez | Group Section | UEFA Champions League 23/24 |
| 2 | Guglielmo Stendardo | Group Stage | UEFA Champions League 07/08 |
| 2 | Luciano Zauri | Group Stage | UEFA Champions League 07/08 |
| 2 | Massimo Mutarelli | Group Stage | UEFA Champions League 07/08 |
| 2 | Sinesa Mihajlovic | Group Stage | UEFA Champions League 03/04 |
| 2 | Bernardo Corradi | Group Stage | UEFA Champions League 03/04 |
| 2 | Massimo Oddo | Group Stage | UEFA Champions League 03/04 |
| 2 | Fernando Couto | Second Group Stage | UEFA Champions League 99/00 |
| 2 | Juan Sebastian Veron | First Group Stage | UEFA Champions League 99/00 |
| 2 | Alessandro Nesta | Second Group Stage | UEFA Champions League 99/00 |
| 2 | Alessandro Nesta | First Group Stage | UEFA Champions League 01/02 |
| 2 | Giuseppe Favalli | First Group Stage | UEFA Champions League 01/02 |
| 2 | Pavel Nedved | First Group Stage | UEFA Champions League 00/01 |
| 2 | Diego Simeone | First Group Stage | UEFA Champions League 00/01 |
| 2 | Dejan Stankovic | First Group Stage | UEFA Champions League 00/01 |
| 2 | Fabrizio Ravanelli | First Group Stage | UEFA Champions League 00/01 |
| 1 | Lucas Leiva | Round of 16 | UEFA Champions League 20/21 |
| 1 | Felipe Caicedo | Group Stage | UEFA Champions League 20/21 |
| 1 | Thomas Strakosha | Group Stage | UEFA Champions League 20/21 |
| 1 | Mohamed Fares | Group Stage | UEFA Champions League 20/21 |
| 1 | Gonzalo Escalante | Round of 16 | UEFA Champions League 20/21 |
| 1 | Szymon Czyz | Group Stage | UEFA Champions League 20/21 |
| 1 | Stefan Radu | Round of 16 | UEFA Champions League 20/21 |
| 1 | Patric | Group Stage | UEFA Champions League 20/21 |
| 1 | Pepe Reina | Group Stage | UEFA Champions League 20/21 |
| 1 | Ciro Immobile | Group Section | UEFA Champions League 23/24 |
| 1 | Adam Marusic | Group Section | UEFA Champions League 23/24 |
| 1 | Danilo Cataldi | Round of 16 | UEFA Champions League 23/24 |
| 1 | Luigi Sepe | Group Section | UEFA Champions League 23/24 |
| 1 | Nicolo Casale | Group Section | UEFA Champions League 23/24 |
| 1 | Luca Pellegrini | Round of 16 | UEFA Champions League 23/24 |
| 1 | Luis Alberto | Group Section | UEFA Champions League 23/24 |
| 1 | Mattia Zaccagni | Group Section | UEFA Champions League 23/24 |
| 1 | Tommaso Rocchi | Group Stage | UEFA Champions League 07/08 |
| 1 | Gaby Mudingayi | Group Stage | UEFA Champions League 07/08 |
| 1 | Emilson Cribari | Group Stage | UEFA Champions League 07/08 |
| 1 | Goran Pandev | Group Stage | UEFA Champions League 07/08 |
| 1 | Lorenzo De Silvestri | Group Stage | UEFA Champions League 07/08 |
| 1 | Giuliano Giannichedda | Group Stage | UEFA Champions League 03/04 |
| 1 | Stefano Fiore | Group Stage | UEFA Champions League 03/04 |
