| 5 | Juanfran | Group Stage | UEFA Champions League 13/14 |
| 4 | Fernandez Gabi | Group Stage | UEFA Champions League 16/17 |
| 4 | Fernandez Gabi | Group Stage | UEFA Champions League 13/14 |
| 4 | Raul Garcia | Group Stage | UEFA Champions League 13/14 |
| 4 | Luis Perea | Group Stage | UEFA Champions League 08/09 |
| 4 | Diego Simeone | Quarter-finals | UEFA Champions League 96/97 |
| 3 | Stefan Savic | Group Stage | UEFA Champions League 22/23 |
| 3 | Marcos Llorente | Group Stage | UEFA Champions League 21/22 |
| 3 | Renan Lodi | Group Stage | UEFA Champions League 20/21 |
| 3 | Jose Maria Gimenez | Group Stage | UEFA Champions League 18/19 |
| 3 | Diego Costa | Group Stage | UEFA Champions League 18/19 |
| 3 | Thomas Partey | Group Stage | UEFA Champions League 18/19 |
| 3 | Filipe Luis | Group Stage | UEFA Champions League 16/17 |
| 3 | Fernandez Gabi | Group Stage | UEFA Champions League 15/16 |
| 3 | Mario Hermoso | Round of 16 | UEFA Champions League 23/24 |
| 3 | Samuel Lino | Group Section | UEFA Champions League 23/24 |
| 3 | Mario Suarez | Group Stage | UEFA Champions League 14/15 |
| 3 | Raul Garcia | Group Stage | UEFA Champions League 14/15 |
| 3 | Diego Godin | Group Stage | UEFA Champions League 14/15 |
| 3 | Jorge Koke | Quarter-finals | UEFA Champions League 13/14 |
| 3 | Paulo Assuncao | Group Stage | UEFA Champions League 09/10 |
| 3 | Santi | Quarter-finals | UEFA Champions League 96/97 |
| 2 | Reinildo Mandava | Group Stage | UEFA Champions League 22/23 |
| 2 | Geoffrey Kondogbia | Group Stage | UEFA Champions League 22/23 |
| 2 | Joao Felix | Group Stage | UEFA Champions League 21/22 |
| 2 | Hector Herrera | Round of 16 | UEFA Champions League 21/22 |
| 2 | Geoffrey Kondogbia | Group Stage | UEFA Champions League 21/22 |
| 2 | Felipe | Group Stage | UEFA Champions League 21/22 |
| 2 | Luis Suarez | Group Stage | UEFA Champions League 21/22 |
| 2 | Angel Correa | Group Stage | UEFA Champions League 21/22 |
| 2 | Rodrigo de Paul | Round of 16 | UEFA Champions League 21/22 |
| 2 | Stefan Savic | Group Stage | UEFA Champions League 20/21 |
| 2 | Marcos Llorente | Group Stage | UEFA Champions League 20/21 |
| 2 | Jorge Koke | Group Stage | UEFA Champions League 20/21 |
| 2 | Saul Niguez | Group Stage | UEFA Champions League 20/21 |
| 2 | Angel Correa | Group Stage | UEFA Champions League 19/20 |
| 2 | Renan Lodi | Group Stage | UEFA Champions League 19/20 |
| 2 | Alvaro Morata | Group Stage | UEFA Champions League 19/20 |
| 2 | Saul Niguez | Group Stage | UEFA Champions League 19/20 |
| 2 | Filipe Luis | Group Stage | UEFA Champions League 18/19 |
| 2 | Angel Correa | Group Stage | UEFA Champions League 18/19 |
| 2 | Antoine Griezmann | Group Stage | UEFA Champions League 18/19 |
| 2 | Jose Maria Gimenez | Group Stage | UEFA Champions League 16/17 |
| 2 | Diego Godin | Group Stage | UEFA Champions League 16/17 |
| 2 | Stefan Savic | Semi-finals | UEFA Champions League 16/17 |
| 2 | Saul Niguez | Group Stage | UEFA Champions League 16/17 |
| 2 | Jorge Koke | Group Stage | UEFA Champions League 16/17 |
| 2 | Saul Niguez | Group Stage | UEFA Champions League 15/16 |
| 2 | Oliver Torres | Group Stage | UEFA Champions League 15/16 |
| 2 | Fernando Torres | Quarter-finals | UEFA Champions League 15/16 |
| 2 | Diego Godin | Group Stage | UEFA Champions League 15/16 |
| 2 | Jorge Koke | Quarter-finals | UEFA Champions League 15/16 |
| 2 | Cesar Azpilicueta | Group Section | UEFA Champions League 23/24 |
| 2 | Jose Maria Gimenez | Group Section | UEFA Champions League 23/24 |
| 2 | Alvaro Morata | Group Section | UEFA Champions League 23/24 |
| 2 | Stefan Savic | Group Section | UEFA Champions League 23/24 |
| 2 | Jorge Koke | Round of 16 | UEFA Champions League 23/24 |
| 2 | Jesus Gamez | Round of 16 | UEFA Champions League 14/15 |
| 2 | Fernandez Gabi | Group Stage | UEFA Champions League 14/15 |
| 2 | Jorge Koke | Group Stage | UEFA Champions League 14/15 |
