| 3 | Rafinha | Group Stage | UEFA Champions League 20/21 |
| 3 | Diogo Figueiras | Group Stage | UEFA Champions League 17/18 |
| 3 | Omar Elabdellaoui | Group Stage | UEFA Champions League 15/16 |
| 3 | Alejandro Dominguez | Group Stage | UEFA Champions League 13/14 |
| 3 | Kostas Manolas | Group Stage | UEFA Champions League 13/14 |
| 3 | Jose Holebas | Group Stage | UEFA Champions League 12/13 |
| 3 | Avraam Papadopoulos | Group Stage | UEFA Champions League 11/12 |
| 3 | Kyriakos Karataidis | Quarter-finals | UEFA Champions League 98/99 |
| 3 | Predrag Djordjevic | Group Stage | UEFA Champions League 07/08 |
| 3 | Milos Maric | Group Stage | UEFA Champions League 06/07 |
| 3 | Anastasios Pantos | Group Stage | UEFA Champions League 04/05 |
| 3 | Georgios Anatolakis | Group Stage | UEFA Champions League 04/05 |
| 3 | Gabriel Schurrer | Group Stage | UEFA Champions League 04/05 |
| 3 | Giovanni | First Group Stage | UEFA Champions League 99/00 |
| 3 | Ze Elias | First Group Stage | UEFA Champions League 00/01 |
| 2 | Mady Camara | Group Stage | UEFA Champions League 20/21 |
| 2 | Kostas Fortounis | Group Stage | UEFA Champions League 20/21 |
| 2 | Guilherme | Group Stage | UEFA Champions League 19/20 |
| 2 | Ruben Semedo | Group Stage | UEFA Champions League 19/20 |
| 2 | Daniel Podence | Group Stage | UEFA Champions League 19/20 |
| 2 | Omar Elabdellaoui | Group Stage | UEFA Champions League 17/18 |
| 2 | Dimitris Nikolaou | Group Stage | UEFA Champions League 17/18 |
| 2 | Alaixys Romao | Group Stage | UEFA Champions League 17/18 |
| 2 | Kostas Fortounis | Group Stage | UEFA Champions League 15/16 |
| 2 | Esteban Cambiasso | Group Stage | UEFA Champions League 15/16 |
| 2 | Giannis Maniatis | Group Stage | UEFA Champions League 14/15 |
| 2 | Alberto Botia | Group Stage | UEFA Champions League 14/15 |
| 2 | Giannis Maniatis | Group Stage | UEFA Champions League 13/14 |
| 2 | Vladimir Weiss | Group Stage | UEFA Champions League 13/14 |
| 2 | David Fuster | Group Stage | UEFA Champions League 13/14 |
| 2 | Pablo Contreras | Group Stage | UEFA Champions League 12/13 |
| 2 | Jose Holebas | Group Stage | UEFA Champions League 11/12 |
| 2 | Olaf Mellberg | Group Stage | UEFA Champions League 09/10 |
| 2 | Avraam Papadopoulos | Round of 16 | UEFA Champions League 09/10 |
| 2 | Dudu Cearense | Group Stage | UEFA Champions League 09/10 |
| 2 | Raul Bravo | Group Stage | UEFA Champions League 09/10 |
| 2 | Vasilis Torosidis | Group Stage | UEFA Champions League 09/10 |
| 2 | Georgios Anatolakis | Quarter-finals | UEFA Champions League 98/99 |
| 2 | Georgios Amanatidas | Group Stage | UEFA Champions League 98/99 |
| 2 | Ilias Poursanidis | Group Stage | UEFA Champions League 98/99 |
| 2 | Dimitrios Mavrogenidis | Group Stage | UEFA Champions League 98/99 |
| 2 | Vasilios Karapialis | Group Stage | UEFA Champions League 98/99 |
| 2 | Grigoris Georgatos | Group Stage | UEFA Champions League 98/99 |
| 2 | Ilija Ivic | Group Stage | UEFA Champions League 97/98 |
| 2 | Mirza Varesanovic | Group Stage | UEFA Champions League 97/98 |
| 2 | Christos Patsatzoglou | Group Stage | UEFA Champions League 07/08 |
| 2 | Cristian Ledesma | Group Stage | UEFA Champions League 07/08 |
| 2 | Paraskevas Antzas | Group Stage | UEFA Champions League 07/08 |
| 2 | Anastasios Pantos | Group Stage | UEFA Champions League 07/08 |
| 2 | Anastasios Pantos | Group Stage | UEFA Champions League 06/07 |
| 2 | Mihalis Konstantinou | Group Stage | UEFA Champions League 06/07 |
| 2 | Ieroklis Stoltidis | Group Stage | UEFA Champions League 05/06 |
| 2 | Nery Castillo | Group Stage | UEFA Champions League 03/04 |
| 2 | Stylianos Venetidis | Group Stage | UEFA Champions League 03/04 |
| 2 | Georgios Anatolakis | Group Stage | UEFA Champions League 03/04 |
| 2 | Predrag Djordjevic | Group Stage | UEFA Champions League 03/04 |
| 2 | Ieroklis Stoltidis | Group Stage | UEFA Champions League 03/04 |
| 2 | Predrag Djordjevic | First Group Stage | UEFA Champions League 02/03 |
| 2 | Edu Dracana | First Group Stage | UEFA Champions League 02/03 |
| 2 | Christian Karembeu | First Group Stage | UEFA Champions League 02/03 |
