| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Ole-Gunnar Solskjaer | 37 | 29 | 8 | 8 | 7 | 9 |
Ryan Giggs | 36 | 32 | 4 | 4 | 8 | 8 |
Mikael Silvestre | 34 | 34 | - | - | 6 | 1 |
Ruud van Nistelrooy | 34 | 33 | 1 | 1 | 11 | 25 |
Paul Scholes | 33 | 31 | 2 | 2 | 6 | 14 |
John O'Shea | 32 | 26 | 10 | 6 | 6 | - |
David Beckham | 31 | 27 | 5 | 4 | 2 | 6 |
Fabian Barthez | 30 | 30 | 1 | - | 3 | - |
Rio Ferdinand | 28 | 27 | 1 | 1 | - | - |
Gary Neville | 26 | 19 | 10 | 7 | 2 | - |
Juan Sebastian Veron | 25 | 21 | 5 | 4 | 9 | 2 |
Phil Neville | 25 | 19 | 15 | 6 | 8 | 1 |
Diego Forlan | 25 | 7 | 27 | 18 | 4 | 6 |
Wes Brown | 22 | 22 | 1 | - | 4 | - |
Roy Keane | 21 | 19 | 2 | 2 | 2 | - |
Laurent Blanc | 19 | 15 | 8 | 4 | 1 | - |
Nicky Butt | 18 | 14 | 6 | 4 | 4 | - |
Roy Carroll | 10 | 8 | 3 | 2 | - | - |
Quinton Fortune | 9 | 5 | 9 | 4 | 2 | - |
Kieran Richardson | 2 | - | 8 | 2 | - | - |
Luke Chadwick | 1 | - | 6 | 1 | - | - |
Michael Stewart | 1 | - | 6 | 1 | - | - |
Lee Roche | 1 | - | 3 | 1 | - | - |
Danny Pugh | 1 | - | 3 | 1 | - | - |
Ricardo | 1 | - | 30 | 1 | - | - |
David May | 1 | - | 5 | 1 | - | - |
Ben Williams | - | - | 3 | - | - | - |
Darren Fletcher | - | - | 4 | - | - | - |
Paul Tierney | - | - | 2 | - | - | - |
Jimmy Davis | - | - | 1 | - | - | - | 503 | 418 | 189 | 85 | 85 | 72 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .