| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Ryan Giggs | 8 | 8 | - | - | 2 | 1 |
Phil Neville | 7 | 7 | 1 | - | 2 | 1 |
Gary Neville | 7 | 7 | 1 | - | - | - |
Ruud van Nistelrooy | 7 | 7 | 1 | - | 2 | 4 |
Tim Howard | 7 | 7 | 1 | - | - | - |
Quinton Fortune | 7 | 6 | 1 | 1 | 1 | 2 |
John O'Shea | 7 | 6 | 2 | 1 | 2 | - |
Rio Ferdinand | 6 | 6 | - | - | 1 | - |
Mikael Silvestre | 6 | 6 | - | - | - | 1 |
Darren Fletcher | 6 | 3 | 4 | 3 | 2 | - |
Paul Scholes | 5 | 5 | - | - | 1 | 1 |
Nicky Butt | 5 | 4 | 4 | 1 | 1 | 1 |
Cristiano Ronaldo | 5 | 3 | 4 | 2 | 2 | - |
Roy Keane | 4 | 4 | 2 | - | - | - |
Diego Forlan | 4 | 2 | 6 | 2 | 1 | 2 |
Eric Djemba-Djemba | 4 | 1 | 6 | 3 | 1 | 1 |
David Bellion | 4 | - | 8 | 4 | - | - |
Wes Brown | 2 | 2 | - | - | - | - |
Louis Saha | 2 | 1 | 1 | 1 | 1 | - |
Ole-Gunnar Solskjaer | 2 | 1 | 1 | 1 | 1 | 1 |
Kleberson | 2 | 1 | 4 | 1 | - | - |
Roy Carroll | 1 | 1 | 7 | - | - | - |
Paul Tierney | - | - | 1 | - | - | - |
Danny Pugh | - | - | 1 | - | - | - | 108 | 88 | 56 | 20 | 20 | 15 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .