| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Paul Scholes | 6 | 6 | - | - | 1 | 4 |
John O'Shea | 6 | 6 | - | - | 1 | - |
Wes Brown | 6 | 5 | 1 | 1 | - | - |
Ryan Giggs | 5 | 5 | - | - | 1 | - |
Mikael Silvestre | 5 | 5 | - | - | 1 | 1 |
Cristiano Ronaldo | 5 | 5 | - | - | 3 | 2 |
Darren Fletcher | 5 | 4 | 2 | 1 | 1 | - |
Roy Keane | 5 | 4 | 2 | 1 | 1 | - |
Nicky Butt | 5 | 3 | 3 | 2 | - | - |
Gary Neville | 4 | 4 | - | - | - | - |
Tim Howard | 4 | 4 | 2 | - | 1 | - |
Ruud van Nistelrooy | 4 | 3 | 1 | 1 | - | 6 |
Quinton Fortune | 3 | 3 | - | - | 1 | - |
Roy Carroll | 3 | 2 | 4 | 1 | - | - |
Phil Neville | 3 | 2 | 2 | 1 | 1 | - |
Ole-Gunnar Solskjaer | 3 | 1 | 2 | 2 | 1 | - |
Diego Forlan | 2 | 2 | 2 | - | 1 | 1 |
David Bellion | 2 | 1 | 2 | 1 | - | - |
Kleberson | 1 | 1 | 1 | - | 1 | - |
Philip Bardsley | 1 | - | 1 | 1 | - | - |
Kieran Richardson | 1 | - | 1 | 1 | - | - |
Danny Pugh | 1 | - | 1 | 1 | - | - |
Eric Djemba-Djemba | 1 | - | 3 | 1 | - | - | 81 | 66 | 30 | 15 | 15 | 14 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .