| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Gabriel Heinze | 7 | 7 | - | - | 1 | - |
Wes Brown | 7 | 6 | 1 | 1 | 2 | - |
Ruud van Nistelrooy | 7 | 6 | 1 | 1 | 3 | 8 |
Cristiano Ronaldo | 7 | 6 | 2 | 1 | 2 | - |
Wayne Rooney | 6 | 6 | - | - | 1 | 3 |
Paul Scholes | 6 | 6 | - | - | 1 | - |
Mikael Silvestre | 6 | 5 | 1 | 1 | - | - |
Roy Carroll | 5 | 5 | 2 | - | - | - |
Roy Keane | 5 | 5 | - | - | 1 | - |
Ryan Giggs | 5 | 5 | 1 | - | 3 | 1 |
Rio Ferdinand | 5 | 5 | - | - | - | - |
Gary Neville | 5 | 5 | - | - | 2 | 1 |
Liam Miller | 4 | 3 | 2 | 1 | 1 | - |
Quinton Fortune | 4 | 2 | 2 | 2 | 1 | - |
Phil Neville | 4 | 1 | 6 | 3 | - | - |
Tim Howard | 3 | 3 | 3 | - | - | - |
Eric Djemba-Djemba | 3 | 3 | 3 | - | - | - |
John O'Shea | 3 | 3 | 4 | - | 1 | - |
Darren Fletcher | 3 | 1 | 3 | 2 | - | - |
Alan Smith | 3 | 1 | 6 | 2 | - | - |
David Bellion | 2 | 2 | 3 | - | - | 1 |
Kleberson | 2 | 1 | 3 | 1 | - | - |
Louis Saha | 2 | - | 3 | 2 | - | - |
Kieran Richardson | 1 | 1 | 1 | - | 1 | - |
Chris Eagles | 1 | - | 1 | 1 | - | - |
Jonathan Spector | 1 | - | 1 | 1 | - | - |
Gerard Pique | 1 | - | 1 | 1 | - | - |
Ricardo | - | - | 3 | - | - | - |
Paul McShane | - | - | 1 | - | - | - |
Sylvan Ebanks-Blake | - | - | 1 | - | - | - |
David Jones | - | - | 1 | - | - | - | 108 | 88 | 56 | 20 | 20 | 14 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .