| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Leon Osman | 35 | 28 | 8 | 7 | 6 | 4 |
Phil Neville | 34 | 34 | - | - | - | - |
Kevin Kilbane | 34 | 21 | 15 | 13 | 8 | - |
David Weir | 33 | 32 | 5 | 1 | - | 1 |
Tim Cahill | 32 | 32 | - | - | 7 | 6 |
James Beattie | 32 | 29 | 3 | 3 | 10 | 10 |
James McFadden | 32 | 24 | 14 | 8 | 10 | 6 |
Simon Davies | 30 | 22 | 14 | 8 | 10 | 1 |
Joseph Yobo | 29 | 29 | 3 | - | - | 1 |
Tony Hibbert | 29 | 29 | 1 | - | 2 | - |
Mikel Arteta | 29 | 27 | 2 | 2 | 9 | 1 |
Duncan Ferguson | 27 | 7 | 20 | 20 | 3 | 1 |
Nuno Valente | 20 | 20 | 2 | - | 2 | - |
Nigel Martyn | 20 | 20 | - | - | 1 | - |
Marcus Bent | 18 | 7 | 14 | 11 | 5 | 1 |
Richard Wright | 15 | 14 | 20 | 1 | 1 | - |
Alan Stubbs | 14 | 13 | 2 | 1 | 1 | - |
Andy van der Meyde | 10 | 7 | 5 | 3 | 7 | - |
Matteo Ferrari | 8 | 6 | 10 | 2 | 2 | - |
Gary Naysmith | 7 | 7 | 10 | - | 2 | - |
Lee Carsley | 5 | 3 | 4 | 2 | - | - |
Iain Turner | 3 | 2 | 13 | 1 | - | - |
Sander Westerveld | 2 | 2 | 1 | - | - | - |
Alessandro Pistone | 2 | 2 | - | - | 1 | - |
Victor Anichebe | 2 | - | 5 | 2 | - | 1 |
Per Kroldrup | 1 | 1 | 9 | - | - | - |
James Vaughan | 1 | - | 2 | 1 | - | - |
John Ruddy | 1 | - | 3 | 1 | - | - |
Bjarni Vidarsson | - | - | 2 | - | - | - |
Li Tie | - | - | 1 | - | - | - | 505 | 418 | 188 | 87 | 87 | 33 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .