| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Paul Robinson | 38 | 38 | - | - | - | - |
Robbie Keane | 36 | 25 | 12 | 11 | 9 | 16 |
Jermain Defoe | 36 | 23 | 15 | 13 | 8 | 9 |
Michael Carrick | 35 | 35 | 1 | - | 1 | 2 |
Paul Stalteri | 33 | 33 | 1 | - | - | 1 |
Michael Dawson | 32 | 31 | 1 | 1 | - | - |
Young-pyo Lee | 31 | 31 | - | - | 3 | - |
Edgar Davids | 31 | 28 | 3 | 3 | 8 | 1 |
Jermaine Jenas | 30 | 30 | - | - | 6 | 6 |
Hossam Mido | 27 | 24 | 4 | 3 | 5 | 11 |
Aaron Lennon | 27 | 21 | 11 | 6 | 16 | 2 |
Ledley King | 26 | 26 | - | - | 2 | 3 |
Teemu Tainio | 24 | 22 | 3 | 2 | 11 | 1 |
Anthony Gardner | 17 | 16 | 8 | 1 | 1 | - |
Andy Reid | 13 | 7 | 9 | 6 | 3 | - |
Danny Murphy | 10 | 2 | 11 | 8 | 2 | - |
Stephen Kelly | 9 | 9 | 11 | - | 1 | - |
Michael Brown | 9 | 2 | 11 | 7 | - | - |
Gregorz Rasiak | 8 | 4 | 7 | 4 | 3 | - |
Pedro Mendes | 6 | 3 | 5 | 3 | 2 | - |
Calum Davenport | 4 | 1 | 6 | 3 | - | - |
Tom Huddlestone | 4 | - | 6 | 4 | - | - |
Erik Edman | 3 | 3 | - | - | - | - |
Noureddine Naybet | 3 | 2 | 11 | 1 | - | - |
Wayne Routledge | 3 | 2 | 1 | 1 | 3 | - |
Lee Barnard | 3 | - | 6 | 3 | - | - |
Noe Pamarot | 2 | - | 6 | 2 | - | - |
Johnnie Jackson | 1 | - | 2 | 1 | - | - |
Frederic Kanoute | 1 | - | 1 | 1 | - | - |
Radek Cerny | - | - | 38 | - | - | - | 502 | 418 | 190 | 84 | 84 | 52 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .