| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Edwin van der Sar | 38 | 38 | - | - | 1 | - |
Rio Ferdinand | 37 | 37 | - | - | 2 | 3 |
Wayne Rooney | 36 | 34 | 2 | 2 | 5 | 16 |
Ruud van Nistelrooy | 35 | 28 | 8 | 7 | 7 | 21 |
John O'Shea | 34 | 34 | - | - | 8 | 1 |
Mikael Silvestre | 33 | 30 | 4 | 3 | 3 | 1 |
Cristiano Ronaldo | 33 | 24 | 10 | 9 | 10 | 9 |
Ji Sung Park | 33 | 23 | 11 | 10 | 11 | 2 |
Darren Fletcher | 27 | 23 | 8 | 4 | 10 | 1 |
Ryan Giggs | 27 | 22 | 6 | 5 | 8 | 2 |
Gary Neville | 25 | 24 | 1 | 1 | 2 | - |
Kieran Richardson | 22 | 12 | 14 | 10 | 6 | 1 |
Alan Smith | 21 | 15 | 6 | 6 | 3 | 1 |
Paul Scholes | 20 | 18 | 2 | 2 | 3 | 2 |
Wes Brown | 19 | 17 | 7 | 2 | 2 | - |
Louis Saha | 19 | 12 | 11 | 7 | 4 | 7 |
Nemanja Vidic | 11 | 9 | 6 | 2 | - | - |
Patrice Evra | 11 | 7 | 9 | 4 | 5 | - |
Philip Bardsley | 8 | 3 | 12 | 5 | 2 | - |
Roy Keane | 5 | 4 | 1 | 1 | 1 | - |
Giuseppe Rossi | 5 | 1 | 13 | 4 | - | 1 |
Gabriel Heinze | 4 | 2 | 4 | 2 | - | - |
Gerard Pique | 3 | 1 | 9 | 2 | - | - |
Ole-Gunnar Solskjaer | 3 | - | 3 | 3 | - | - |
Liam Miller | 1 | - | 3 | 1 | - | - |
Tim Howard | 1 | - | 37 | 1 | - | - |
Ritchie Jones | - | - | 1 | - | - | - |
Luke Steele | - | - | 1 | - | - | - |
Quinton Fortune | - | - | 1 | - | - | - | 511 | 418 | 190 | 93 | 93 | 68 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .