| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Mikael Silvestre | 4 | 4 | - | - | 1 | - |
Wes Brown | 4 | 4 | - | - | 2 | - |
Kieran Richardson | 4 | 4 | - | - | 1 | 3 |
Louis Saha | 4 | 3 | 1 | 1 | 1 | 2 |
Darren Fletcher | 3 | 2 | 1 | 1 | 2 | - |
Gary Neville | 3 | 2 | 1 | 1 | - | - |
Wayne Rooney | 3 | 2 | 1 | 1 | - | - |
Philip Bardsley | 2 | 2 | 1 | - | - | - |
Nemanja Vidic | 2 | 2 | - | - | - | - |
Ruud van Nistelrooy | 2 | 2 | 1 | - | - | - |
Edwin van der Sar | 2 | 2 | 1 | - | - | - |
Tim Howard | 2 | 2 | 2 | - | - | - |
John O'Shea | 2 | 2 | - | - | 1 | - |
Gerard Pique | 2 | 2 | 1 | - | - | - |
Giuseppe Rossi | 2 | 2 | - | - | 1 | 2 |
Ole-Gunnar Solskjaer | 2 | 2 | - | - | 1 | - |
Rio Ferdinand | 2 | 1 | 1 | 1 | - | - |
Cristiano Ronaldo | 2 | 1 | 1 | 1 | - | - |
Ryan Giggs | 2 | 1 | 1 | 1 | - | 1 |
Ji Sung Park | 2 | 1 | 1 | 1 | - | - |
Alan Smith | 2 | - | 2 | 2 | 1 | - |
Ritchie Jones | 1 | 1 | - | - | - | - |
Patrice Evra | 1 | - | 1 | 1 | - | - |
Adam Eckersley | - | - | 1 | - | - | - |
Fraizer Campbell | - | - | 1 | - | - | - |
Luke Steele | - | - | 1 | - | - | - | 55 | 44 | 20 | 11 | 11 | 8 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .