| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Paul Robinson | 38 | 38 | - | - | - | 1 |
Michael Dawson | 37 | 37 | - | - | 2 | 1 |
Jermain Defoe | 34 | 20 | 17 | 14 | 8 | 10 |
Pascal Chimbonda | 33 | 33 | - | - | 3 | 1 |
Dimitar Berbatov | 33 | 30 | 4 | 3 | 3 | 12 |
Didier Zokora | 31 | 26 | 6 | 5 | 7 | - |
Robbie Keane | 27 | 18 | 12 | 9 | 8 | 11 |
Aaron Lennon | 26 | 22 | 4 | 4 | 6 | 3 |
Jermaine Jenas | 25 | 24 | 1 | 1 | 2 | 6 |
Steed Malbranque | 25 | 18 | 7 | 7 | 9 | 2 |
Ledley King | 21 | 21 | - | - | 1 | - |
Teemu Tainio | 21 | 20 | 1 | 1 | 12 | 2 |
Young-pyo Lee | 21 | 20 | 4 | 1 | 4 | - |
Hossam Ghaly | 21 | 17 | 7 | 4 | 8 | 1 |
Tom Huddlestone | 21 | 15 | 15 | 6 | - | 1 |
Benoit Assou-Ekotto | 16 | 16 | 4 | - | 1 | - |
Hossam Mido | 12 | 7 | 8 | 5 | 2 | 1 |
Danny Murphy | 12 | 5 | 12 | 7 | 2 | 1 |
Calum Davenport | 10 | 8 | 3 | 2 | 1 | 1 |
Ricardo Rocha | 9 | 9 | 2 | - | 1 | - |
Edgar Davids | 9 | 6 | 6 | 3 | 2 | - |
Anthony Gardner | 8 | 6 | 10 | 2 | - | - |
Paul Stalteri | 6 | 1 | 12 | 5 | - | 1 |
Adel Taarabt | 2 | - | 3 | 2 | - | - |
Philip Ifil | 1 | 1 | 4 | - | - | - |
Reto Ziegler | 1 | - | 6 | 1 | - | - |
Jamie O'Hara | - | - | 2 | - | - | - |
Charlie Lee | - | - | 1 | - | - | - |
Radek Cerny | - | - | 38 | - | - | - | 500 | 418 | 189 | 82 | 82 | 55 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .