| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Steven Gerrard | 36 | 35 | 1 | 1 | 8 | 7 |
Pepe Reina | 35 | 35 | - | - | - | - |
Jamie Carragher | 35 | 34 | 1 | 1 | 3 | 1 |
Dirk Kuyt | 34 | 27 | 8 | 7 | 13 | 12 |
Jermaine Pennant | 34 | 20 | 15 | 14 | 9 | 1 |
Steve Finnan | 33 | 32 | 1 | 1 | 1 | - |
John Arne Riise | 33 | 29 | 4 | 4 | 2 | 1 |
Xabi Alonso | 32 | 29 | 3 | 3 | 2 | 4 |
Peter Crouch | 32 | 19 | 15 | 13 | 14 | 9 |
Craig Bellamy | 27 | 23 | 4 | 4 | 12 | 7 |
Daniel Agger | 27 | 23 | 11 | 4 | - | 2 |
Mark Gonzalez | 25 | 14 | 13 | 11 | 12 | 2 |
Sami Hyypia | 23 | 23 | 13 | - | 2 | 2 |
Luis Garcia | 17 | 11 | 6 | 6 | 6 | 3 |
Fabio Aurelio | 17 | 10 | 7 | 7 | 1 | - |
Mohamed Sissoko | 16 | 15 | 2 | 1 | 7 | - |
Boudewijn Zenden | 16 | 9 | 10 | 7 | 4 | - |
Robbie Fowler | 16 | 6 | 14 | 10 | 3 | 3 |
Alvaro Arbeloa | 9 | 8 | 1 | 1 | 1 | 1 |
Javier Mascherano | 7 | 7 | 1 | - | 2 | - |
Gabriel Paletta | 3 | 2 | 7 | 1 | - | - |
Danny Guthrie | 3 | - | 4 | 3 | - | - |
Nabil El Zhar | 3 | - | 3 | 3 | - | - |
Jerzy Dudek | 2 | 2 | 31 | - | - | - |
Emiliano Insua | 2 | 2 | - | - | 1 | - |
Harry Kewell | 2 | - | 2 | 2 | - | 1 |
Jan Kromkamp | 1 | 1 | 1 | - | - | - |
Stephen Warnock | 1 | 1 | 3 | - | 1 | - |
Daniele Padelli | 1 | 1 | 3 | - | - | - |
Jack Hobbs | - | - | 2 | - | - | - |
David Martin | - | - | 2 | - | - | - | 522 | 418 | 188 | 104 | 104 | 56 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .