| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Rio Ferdinand | 7 | 7 | - | - | 1 | - |
Michael Carrick | 7 | 7 | - | - | 2 | 1 |
Cristiano Ronaldo | 7 | 6 | 1 | 1 | 1 | 3 |
Wayne Rooney | 7 | 5 | 2 | 2 | - | 5 |
Wes Brown | 6 | 6 | 1 | - | - | - |
Gabriel Heinze | 6 | 6 | 1 | - | 1 | 1 |
Ryan Giggs | 6 | 6 | - | - | 3 | - |
Ole-Gunnar Solskjaer | 6 | 3 | 3 | 3 | 3 | 2 |
Darren Fletcher | 6 | 3 | 3 | 3 | 1 | - |
Nemanja Vidic | 5 | 5 | - | - | - | - |
Tomasz Kuszczak | 5 | 5 | 3 | - | - | - |
Ji Sung Park | 5 | 4 | 2 | 1 | 2 | - |
John O'Shea | 5 | 2 | 5 | 3 | - | - |
Paul Scholes | 4 | 3 | 2 | 1 | - | - |
Patrice Evra | 4 | 3 | 2 | 1 | - | - |
Henrik Larsson | 4 | 3 | 1 | 1 | 1 | 1 |
Edwin van der Sar | 3 | 3 | 2 | - | - | - |
Gary Neville | 3 | 3 | - | - | - | - |
Kieran Richardson | 3 | 2 | 2 | 1 | 1 | 1 |
Alan Smith | 3 | 2 | 3 | 1 | 1 | - |
Louis Saha | 2 | 2 | - | - | 1 | 1 |
Mikael Silvestre | 2 | 2 | 1 | - | - | - |
Chris Eagles | - | - | 2 | - | - | - |
Craig Cathcart | - | - | 2 | - | - | - |
Tom Heaton | - | - | 2 | - | - | - | 106 | 88 | 40 | 18 | 18 | 15 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .