| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Nicky Butt | 35 | 35 | 1 | - | 5 | 3 |
Alan Smith | 33 | 26 | 9 | 7 | 3 | - |
Charles N'Zogbia | 32 | 27 | 5 | 5 | 2 | 3 |
Steven Taylor | 31 | 29 | 3 | 2 | 3 | 1 |
Obafemi Martins | 31 | 23 | 8 | 8 | 12 | 9 |
Habib Beye | 29 | 27 | 2 | 2 | 1 | 1 |
James Milner | 29 | 25 | 4 | 4 | 7 | 2 |
Michael Owen | 29 | 24 | 5 | 5 | 6 | 11 |
Geremi | 27 | 24 | 5 | 3 | 10 | 1 |
Mark Viduka | 26 | 19 | 8 | 7 | 12 | 7 |
Joey Barton | 23 | 20 | 3 | 3 | 3 | 1 |
Jose Enrique | 23 | 18 | 10 | 5 | 5 | - |
Abdoulaye Faye | 22 | 20 | 4 | 2 | 6 | 1 |
Steve Harper | 21 | 19 | 18 | 2 | - | - |
David Rozehnal | 21 | 16 | 7 | 5 | 2 | - |
Shay Given | 19 | 19 | 4 | - | 2 | - |
Claudio Cacapa | 19 | 16 | 10 | 3 | 2 | 1 |
Damien Duff | 16 | 12 | 7 | 4 | 6 | - |
Emre Belozoglu | 14 | 6 | 12 | 8 | 4 | 1 |
Stephen Carr | 10 | 8 | 2 | 2 | 2 | - |
Shola Ameobi | 6 | 2 | 8 | 4 | - | - |
David Edgar | 5 | 2 | 12 | 3 | 1 | - |
Andy Carroll | 4 | 1 | 11 | 3 | - | - |
Peter Ramage | 3 | - | 4 | 3 | 1 | - |
Lamine Diatta | 2 | - | 2 | 2 | - | - |
Kazenga LuaLua | 2 | - | 4 | 2 | - | - |
Nolberto Solano | 1 | - | 1 | 1 | - | - |
Matthew Pattison | - | - | 3 | - | - | - |
Ben Tozer | - | - | 1 | - | - | - |
Fraser Forster | - | - | 16 | - | - | - |
James Troisi | - | - | 1 | - | - | - | 513 | 418 | 190 | 95 | 95 | 42 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .