| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Michael Carrick | 12 | 11 | 1 | 1 | 1 | - |
Carlos Tevez | 12 | 6 | 6 | 6 | 3 | 4 |
Cristiano Ronaldo | 11 | 11 | 1 | - | 2 | 8 |
Rio Ferdinand | 11 | 11 | - | - | - | 1 |
Wayne Rooney | 11 | 10 | 1 | 1 | 6 | 4 |
Nani | 11 | 7 | 4 | 4 | 3 | - |
Patrice Evra | 10 | 10 | 1 | - | 1 | - |
Edwin van der Sar | 10 | 10 | 1 | - | 2 | - |
Wes Brown | 10 | 9 | 3 | 1 | 1 | - |
Nemanja Vidic | 9 | 9 | - | - | - | - |
Anderson | 9 | 6 | 6 | 3 | 3 | - |
Ryan Giggs | 9 | 4 | 6 | 5 | 4 | - |
Owen Hargreaves | 8 | 5 | 3 | 3 | 1 | - |
Paul Scholes | 7 | 7 | 2 | - | 3 | 1 |
Darren Fletcher | 6 | 5 | 3 | 1 | 1 | - |
John O'Shea | 5 | 4 | 8 | 1 | 1 | - |
Louis Saha | 5 | 3 | 4 | 2 | 2 | - |
Tomasz Kuszczak | 5 | 3 | 10 | 2 | - | - |
Ji Sung Park | 4 | 4 | 1 | - | - | - |
Gerard Pique | 3 | 3 | 6 | - | 1 | 2 |
Danny Simpson | 3 | 2 | 3 | 1 | - | - |
Mikael Silvestre | 2 | 1 | 4 | 1 | - | - |
Jonny Evans | 2 | 1 | 3 | 1 | - | - |
Chris Eagles | 1 | 1 | 4 | - | - | - |
Gary Neville | 1 | - | 1 | 1 | - | - |
FangZhou Dong | 1 | - | 1 | 1 | - | - |
Sam Hewson | - | - | 1 | - | - | - |
Kieran Lee | - | - | 1 | - | - | - |
Adam Eckersley | - | - | 1 | - | - | - |
Fabian Brandy | - | - | 1 | - | - | - |
Tom Heaton | - | - | 2 | - | - | - |
Danny Welbeck | - | - | 2 | - | - | - | 178 | 143 | 91 | 35 | 35 | 20 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .