| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Rene Adler | 34 | 34 | - | - | - | - |
Simon Rolfes | 34 | 34 | - | - | 1 | 8 |
Gonzalo Castro | 33 | 33 | - | - | 2 | 1 |
Manuel Friedrich | 32 | 32 | 2 | - | 1 | 4 |
Tranquillo Barnetta | 32 | 31 | 1 | 1 | 9 | 6 |
Stefan Kiessling | 31 | 31 | - | - | 4 | 9 |
Sergej Barbarez | 29 | 26 | 3 | 3 | 14 | 4 |
Theofanis Gekas | 28 | 20 | 12 | 8 | 12 | 12 |
Hans Sarpei | 26 | 22 | 6 | 4 | 7 | - |
Karim Haggui | 24 | 24 | - | - | 2 | 2 |
Arturo Vidal | 23 | 17 | 8 | 6 | 10 | 1 |
Vratislav Gresko | 21 | 15 | 12 | 6 | 3 | - |
Lukas Sinkiewicz | 19 | 12 | 12 | 7 | 2 | 2 |
Paul Freier | 18 | 7 | 15 | 11 | 6 | 2 |
Sascha Dum | 17 | 1 | 19 | 16 | 1 | - |
Bernd Schneider | 15 | 13 | 4 | 2 | 6 | - |
Dmitri Bulykin | 13 | 5 | 16 | 8 | 4 | 2 |
Pirmin Schwegler | 11 | 6 | 13 | 5 | 5 | - |
Jan-Ingwer Callsen-Braker | 10 | 6 | 10 | 4 | - | - |
Michal Papadopulos | 7 | 1 | 6 | 6 | 1 | - |
Carsten Ramelow | 4 | 3 | 4 | 1 | 2 | 1 |
Marcel Risse | 3 | 1 | 2 | 2 | 1 | - |
Ricardo Faty | 2 | - | 3 | 2 | - | - |
Jens Hegeler | 1 | - | 2 | 1 | - | - |
Benedikt Fernandez | - | - | 13 | - | - | - |
Kim Falkenberg | - | - | 1 | - | - | - |
Eric Domaschke | - | - | 5 | - | - | - | 467 | 374 | 169 | 93 | 93 | 54 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .