| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Raul | 37 | 36 | 1 | 1 | 9 | 18 |
Iker Casillas | 36 | 36 | - | - | - | - |
Sergio Ramos | 33 | 33 | - | - | 3 | 5 |
Fabio Cannavaro | 33 | 33 | - | - | 4 | - |
Robinho | 32 | 27 | 5 | 5 | 19 | 11 |
Guti | 32 | 27 | 5 | 5 | 5 | 3 |
Fernando Gago | 31 | 21 | 14 | 10 | 3 | - |
Wesley Sneijder | 30 | 27 | 5 | 3 | 18 | 9 |
Mahamadou Diarra | 30 | 25 | 7 | 5 | 5 | - |
Julio Baptista | 27 | 13 | 18 | 14 | 8 | 3 |
Gonzalo Higuain | 25 | 7 | 21 | 18 | 7 | 8 |
Marcelo | 24 | 24 | 5 | - | 3 | - |
Ruud van Nistelrooy | 24 | 22 | 3 | 2 | 7 | 16 |
Arjen Robben | 21 | 12 | 10 | 9 | 4 | 4 |
Gabriel Heinze | 20 | 17 | 8 | 3 | 3 | 1 |
Miguel Torres | 20 | 13 | 9 | 7 | 1 | - |
Pepe | 19 | 17 | 2 | 2 | 1 | - |
Roysten Drenthe | 18 | 7 | 16 | 11 | 5 | 2 |
Christoph Metzelder | 9 | 7 | 5 | 2 | - | - |
Javier Saviola | 9 | 5 | 13 | 4 | 3 | 3 |
Michel Salgado | 8 | 6 | 9 | 2 | 3 | - |
Roberto Soldado | 5 | 1 | 9 | 4 | 1 | - |
Javier Balboa | 5 | - | 11 | 5 | - | - |
Jordi Codina | 1 | 1 | 2 | - | - | - |
Jerzy Dudek | 1 | 1 | 19 | - | - | - | 530 | 418 | 197 | 112 | 112 | 83 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .