| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 David Silva | 34 | 32 | 2 | 2 | 11 | 5 |
Joaquin | 34 | 26 | 10 | 8 | 9 | 3 |
Raul Albiol | 32 | 32 | - | - | - | 1 |
Javier Arizmendi | 30 | 18 | 14 | 12 | 7 | 1 |
Emiliano Moretti | 28 | 28 | - | - | 1 | 1 |
Carlos Marchena | 28 | 26 | 4 | 2 | 4 | - |
David Villa | 28 | 26 | 2 | 2 | 13 | 18 |
Timo Hildebrand | 27 | 27 | 4 | - | 1 | - |
Miguel | 26 | 23 | 5 | 3 | 3 | 1 |
Ruben Baraja | 25 | 22 | 4 | 3 | 7 | 2 |
Juan Mata | 24 | 17 | 10 | 7 | 12 | 5 |
Ivan Helguera | 23 | 21 | 8 | 2 | 1 | 1 |
Fernando Morientes | 22 | 11 | 11 | 11 | 8 | 6 |
Marco Caneira | 19 | 19 | 2 | - | 4 | - |
Vicente | 17 | 7 | 12 | 10 | 6 | - |
Miguel Angel Angulo | 16 | 9 | 7 | 7 | 3 | 2 |
David Albelda | 15 | 11 | 7 | 4 | 2 | - |
Nikola Zigic | 15 | 3 | 18 | 12 | 2 | 1 |
Alexis | 14 | 12 | 6 | 2 | 2 | - |
Edu | 13 | 3 | 12 | 10 | 1 | - |
Ever Banega | 12 | 7 | 5 | 5 | 4 | - |
Hedwiges Maduro | 11 | 11 | 1 | - | 5 | - |
Santiago Canizares | 10 | 10 | 2 | - | - | - |
Sunny | 10 | 4 | 10 | 6 | 2 | - |
Manuel Fernandes | 7 | 5 | 4 | 2 | 3 | - |
Angel Montoro | 4 | 3 | 3 | 1 | 1 | - |
Jaime Gavilan | 3 | 2 | 2 | 1 | 2 | - |
David Lomban | 3 | 1 | 4 | 2 | - | - |
Juan Luis Mora | 2 | 2 | 9 | - | - | - | 532 | 418 | 178 | 114 | 114 | 47 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .