| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Joan Capdevila | 36 | 36 | - | - | - | 2 |
Santi Cazorla | 36 | 28 | 8 | 8 | 6 | 5 |
Marcos Senna | 34 | 34 | 1 | - | 8 | 4 |
Nihat Kahveci | 34 | 25 | 10 | 9 | 17 | 18 |
Robert Pires | 32 | 27 | 5 | 5 | 19 | 3 |
Cani | 31 | 14 | 20 | 17 | 4 | - |
Matias Fernandez | 30 | 11 | 20 | 19 | 8 | 3 |
Giuseppe Rossi | 27 | 22 | 5 | 5 | 13 | 11 |
Javi Venta | 25 | 23 | 4 | 2 | 2 | 1 |
Jon Dahl Tomasson | 25 | 9 | 19 | 16 | 8 | 3 |
Diego Godin | 24 | 22 | 7 | 2 | - | 1 |
Guillermo Franco | 24 | 16 | 10 | 8 | 8 | 9 |
Bruno Soriano | 21 | 16 | 8 | 5 | 6 | - |
Diego Lopez | 20 | 20 | 7 | - | - | - |
Pascal Cygan | 20 | 19 | 4 | 1 | 1 | 1 |
Angel Lopez | 20 | 17 | 5 | 3 | 1 | - |
Fabricio Fuentas | 18 | 18 | - | - | 1 | 2 |
Sebastian Viera | 18 | 18 | 5 | - | - | - |
Gonzalo Rodriguez | 18 | 17 | 2 | 1 | - | - |
Sebastian Eguren | 15 | 14 | 1 | 1 | 3 | - |
Josico | 13 | 10 | 4 | 3 | 5 | - |
Rio Mavuba | 5 | 1 | 6 | 4 | - | - |
Josemi | 1 | 1 | 7 | - | - | - |
Juan Carlos | 1 | - | 1 | 1 | - | - | 528 | 418 | 159 | 110 | 110 | 63 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .