| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Sergio Aguero | 37 | 35 | 2 | 2 | 14 | 20 |
Diego Forlan | 36 | 35 | 1 | 1 | 9 | 16 |
Maxi Rodriguez | 36 | 32 | 3 | 4 | 11 | 8 |
Raul Garcia | 34 | 34 | - | - | 9 | 3 |
Pablo Ibanez | 34 | 34 | - | - | - | 1 |
Luis Garcia | 31 | 13 | 20 | 18 | 6 | 2 |
Luis Perea | 30 | 30 | - | - | 3 | - |
Mariano Pernia | 29 | 28 | 3 | 1 | 3 | 1 |
Simao Sabrosa | 29 | 25 | 5 | 4 | 20 | 7 |
Jose Antonio Reyes | 26 | 10 | 17 | 16 | 8 | - |
Antonio Lopez | 24 | 23 | 6 | 1 | - | 1 |
Cleber Santana | 23 | 11 | 18 | 12 | 3 | - |
Christian Abbiati | 21 | 20 | 8 | 1 | - | - |
Leo Franco | 18 | 18 | 1 | - | 1 | - |
Fabiano Eller | 18 | 14 | 7 | 4 | 3 | - |
Jose Manuel Jurado | 16 | 3 | 15 | 13 | 1 | 2 |
Maniche | 15 | 15 | - | - | 1 | 2 |
Georgios Seitaridis | 14 | 12 | 3 | 2 | 2 | - |
Miguel de las Cuevas | 13 | 1 | 14 | 12 | - | - |
Ignacio Camacho | 10 | 9 | 1 | 1 | 5 | 2 |
Jose Ze Castro | 8 | 6 | 6 | 2 | 2 | - |
Juan Valera | 8 | 5 | 6 | 3 | 1 | - |
Thiago Motta | 6 | 3 | 3 | 3 | 1 | - |
Mista | 6 | 2 | 10 | 4 | 2 | - |
Joshua | 1 | - | 1 | 1 | - | - |
Ismael Falcon | - | - | 2 | - | - | - | 523 | 418 | 152 | 105 | 105 | 65 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .