| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Jesus Navas | 36 | 32 | 4 | 4 | 8 | 4 |
Dani Alves | 33 | 33 | - | - | 2 | 2 |
Seydou Keita | 31 | 28 | 3 | 3 | 2 | 4 |
Andres Palop | 30 | 30 | 1 | - | 1 | - |
Luis Fabiano | 30 | 28 | 3 | 2 | 12 | 24 |
Frederic Kanoute | 30 | 25 | 5 | 5 | 9 | 16 |
Diego Capel | 30 | 22 | 10 | 8 | 14 | 3 |
Christian Poulsen | 29 | 23 | 9 | 6 | 9 | 3 |
Renato | 28 | 17 | 13 | 11 | 8 | 4 |
Adriano | 27 | 23 | 4 | 4 | 10 | 1 |
Aquivaldo Mosquera | 24 | 23 | 4 | 1 | 3 | - |
Ivica Dragutinovic | 23 | 23 | 1 | - | 3 | 1 |
Federico Fazio | 23 | 19 | 5 | 4 | 3 | 3 |
Enzo Maresca | 21 | 12 | 11 | 9 | 5 | 1 |
Arouna Kone | 20 | 7 | 18 | 13 | 4 | 1 |
Duda | 17 | 5 | 15 | 12 | 3 | - |
Julien Escude | 16 | 15 | 1 | 1 | 1 | - |
Jose Angel Crespo | 13 | 13 | 1 | - | 4 | - |
Aleksandr Kerzhakov | 11 | 6 | 5 | 5 | 3 | 3 |
David Prieto | 9 | 8 | 2 | 1 | - | - |
Jose Luis Marti | 9 | 4 | 10 | 5 | - | - |
Morgan De Sanctis | 8 | 7 | 16 | 1 | - | - |
Javier Ernesto Chevanton | 8 | 1 | 7 | 7 | 1 | 1 |
Khalid Boulahrouz | 6 | 6 | 3 | - | 1 | - |
Tom de Mul | 6 | 3 | 12 | 3 | 2 | - |
Andreas Hinkel | 2 | 2 | 3 | - | - | - |
Lolo | 2 | 1 | 2 | 1 | - | - |
Antonio Puerta | 1 | 1 | - | - | 1 | - |
Pablo Vargas | 1 | 1 | - | - | - | - |
Juanjo | 1 | - | 2 | 1 | - | - |
Jose Manuel Casado | 1 | - | 1 | 1 | - | - |
Alejandro Alfaro | 1 | - | 1 | 1 | - | - | 527 | 418 | 172 | 109 | 109 | 71 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .