| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Fabricio Coloccini | 34 | 34 | 3 | - | 1 | - |
Nicky Butt | 33 | 33 | 1 | - | 4 | - |
Damien Duff | 30 | 28 | 4 | 2 | 3 | 3 |
Sebastien Bassong | 30 | 26 | 9 | 4 | 2 | - |
Jonas Gutierrez | 30 | 23 | 9 | 7 | 7 | - |
Michael Owen | 28 | 21 | 7 | 7 | 5 | 8 |
Steven Taylor | 27 | 25 | 6 | 2 | 2 | 4 |
Jose Enrique | 26 | 24 | 5 | 2 | 6 | - |
Obafemi Martins | 24 | 21 | 3 | 3 | 11 | 8 |
Danny Guthrie | 24 | 21 | 7 | 3 | 3 | 2 |
Habib Beye | 23 | 22 | 1 | 1 | 2 | - |
Shay Given | 22 | 22 | - | - | - | - |
Shola Ameobi | 22 | 14 | 12 | 8 | 8 | 4 |
Charles N'Zogbia | 18 | 14 | 8 | 4 | 2 | 1 |
Steve Harper | 16 | 16 | 22 | - | - | - |
Geremi | 15 | 11 | 18 | 4 | 6 | - |
Andy Carroll | 14 | 5 | 19 | 9 | 2 | 3 |
Peter Lovenkrands | 12 | 8 | 6 | 4 | 6 | 3 |
Mark Viduka | 12 | 6 | 8 | 6 | 6 | - |
Kevin Nolan | 11 | 10 | 1 | 1 | 3 | - |
David Edgar | 11 | 7 | 22 | 4 | 2 | 1 |
Ryan Taylor | 10 | 8 | 4 | 2 | 1 | - |
Joey Barton | 9 | 6 | 4 | 3 | 2 | 1 |
Alan Smith | 6 | 4 | 10 | 2 | 2 | - |
Claudio Cacapa | 6 | 4 | 13 | 2 | 1 | - |
Xisco | 5 | 3 | 12 | 2 | - | 1 |
Kazenga LuaLua | 3 | - | 9 | 3 | - | - |
James Milner | 2 | 2 | - | - | - | - |
Ignacio Gonzalez | 2 | - | 2 | 2 | - | - |
Tim Krul | - | - | 11 | - | - | - |
Frank Waife | - | - | 1 | - | - | - |
Mark Doninger | - | - | 4 | - | - | - |
Tamas Kadar | - | - | 3 | - | - | - |
Fraser Forster | - | - | 5 | - | - | - |
Nile Ranger | - | - | 3 | - | - | - |
Bradden Inman | - | - | 1 | - | - | - |
Ben Tozer | - | - | 3 | - | - | - |
Ryan Donaldson | - | - | 9 | - | - | - | 505 | 418 | 265 | 87 | 87 | 39 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .