| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Brad Friedel | 38 | 38 | - | - | - | - |
Gareth Barry | 38 | 38 | - | - | 1 | 5 |
Ashley Young | 36 | 36 | - | - | 4 | 7 |
Stilian Petrov | 36 | 36 | - | - | 5 | 1 |
Gabriel Agbonlahor | 36 | 35 | 1 | 1 | 5 | 11 |
James Milner | 36 | 31 | 5 | 5 | 3 | 3 |
Curtis Davies | 35 | 34 | 4 | 1 | 3 | 1 |
Luke Young | 34 | 33 | 1 | 1 | 3 | 1 |
Carlos Cuellar | 28 | 24 | 5 | 4 | 3 | - |
John Carew | 27 | 18 | 10 | 9 | 7 | 11 |
Nigel Reo-Coker | 26 | 19 | 13 | 7 | 3 | 1 |
Nicky Shorey | 21 | 19 | 18 | 2 | 8 | - |
Martin Laursen | 19 | 19 | - | - | 1 | 1 |
Steve Sidwell | 16 | 11 | 15 | 5 | 4 | 3 |
Emile Heskey | 14 | 11 | 3 | 3 | 7 | 2 |
Craig Gardner | 14 | 3 | 35 | 11 | 3 | - |
Zatyiah Knight | 13 | 13 | 25 | - | 1 | 1 |
Marlon Harewood | 6 | - | 26 | 6 | - | - |
Nathan Delfouneso | 4 | - | 25 | 4 | - | - |
Brad Guzan | 1 | - | 36 | 1 | - | - |
Wayne Routledge | 1 | - | 5 | 1 | - | - |
Stuart Taylor | - | - | 2 | - | - | - |
Moustapha Salifou | - | - | 23 | - | - | - |
Isaiah Osbourne | - | - | 6 | - | - | - |
Marc Albrighton | - | - | 4 | - | - | - |
Ciaran Clark | - | - | 4 | - | - | - | 479 | 418 | 266 | 61 | 61 | 48 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .