| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Iker Casillas | 38 | 38 | - | - | - | - |
Raul | 37 | 35 | 2 | 2 | 13 | 18 |
Gonzalo Higuain | 34 | 31 | 4 | 3 | 13 | 22 |
Sergio Ramos | 32 | 32 | 1 | - | 2 | 4 |
Rafael van der Vaart | 32 | 15 | 19 | 17 | 12 | 5 |
Fabio Cannavaro | 29 | 29 | 1 | - | 5 | - |
Arjen Robben | 29 | 25 | 4 | 4 | 12 | 7 |
Marcelo | 27 | 24 | 4 | 3 | 7 | 4 |
Pepe | 26 | 26 | - | - | 2 | - |
Fernando Gago | 26 | 24 | 4 | 2 | 1 | 1 |
Gabriel Heinze | 24 | 24 | 2 | - | 4 | 2 |
Wesley Sneijder | 22 | 18 | 4 | 4 | 14 | 2 |
Klass - Jan Huntelaar | 20 | 13 | 9 | 7 | 7 | 8 |
Roysten Drenthe | 20 | 5 | 22 | 15 | 2 | - |
Guti | 18 | 13 | 6 | 5 | 5 | 3 |
Lassana Diarra | 16 | 16 | - | - | 1 | - |
Javi Garcia | 15 | 3 | 15 | 12 | 1 | - |
Miguel Torres | 14 | 9 | 12 | 5 | 2 | - |
Mahamadou Diarra | 12 | 10 | 2 | 2 | 2 | - |
Christoph Metzelder | 12 | 9 | 12 | 3 | - | - |
Michel Salgado | 9 | 6 | 8 | 3 | - | - |
Javier Saviola | 8 | 1 | 17 | 7 | - | 1 |
Ruben de la Red | 7 | 5 | 4 | 2 | 3 | 1 |
Ruud van Nistelrooy | 6 | 6 | - | - | 1 | 4 |
Daniel Parejo | 5 | - | 9 | 5 | - | - |
Alberto Bueno | 3 | - | 4 | 3 | - | - |
Miguel Palanca | 3 | - | 3 | 3 | - | - |
Julian Faubert | 2 | - | 5 | 2 | - | - |
Gary Kagelmacher | 1 | 1 | - | - | 1 | - |
Marcos Tebar | 1 | - | 1 | 1 | - | - |
Jerzy Dudek | - | - | 19 | - | - | - |
Jordi Codina | - | - | 2 | - | - | - |
Agustin Garcia | - | - | 1 | - | - | - |
Javier Velayos | - | - | 1 | - | - | - | 528 | 418 | 197 | 110 | 110 | 82 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .