| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Samuel Eto'o | 36 | 34 | 3 | 2 | 14 | 30 |
Victor Valdes | 35 | 35 | 2 | - | - | - |
Xavi | 35 | 34 | 3 | 1 | 10 | 6 |
Dani Alves | 34 | 32 | 2 | 2 | 2 | 5 |
Lionel Messi | 31 | 27 | 6 | 4 | 4 | 23 |
Thierry Henry | 29 | 24 | 7 | 5 | 11 | 19 |
Seydou Keita | 29 | 17 | 15 | 12 | 9 | 4 |
Carles Puyol | 28 | 26 | 4 | 2 | 4 | 1 |
Andres Iniesta | 26 | 22 | 4 | 4 | 12 | 4 |
Eric Abidal | 25 | 25 | 3 | - | 2 | - |
Gerard Pique | 25 | 25 | 1 | - | 1 | 1 |
Yaya Toure | 25 | 23 | 5 | 2 | 7 | 2 |
Eidur Gudjohnsen | 24 | 11 | 18 | 13 | 5 | 3 |
Rafael Marquez (Mex) | 23 | 23 | 1 | - | 4 | 1 |
Sergio Busquets | 23 | 15 | 14 | 8 | 4 | 1 |
Bojan Krkic | 23 | 6 | 26 | 17 | 3 | 2 |
Aliaksandr Hleb | 19 | 8 | 18 | 11 | 4 | - |
Silvinho | 15 | 10 | 10 | 5 | 4 | - |
Martin Caceres | 13 | 8 | 13 | 5 | - | - |
Pedro Rodriguez | 7 | 5 | 3 | 2 | 3 | - |
Victor Sanchez | 7 | 3 | 8 | 4 | 2 | - |
Xavi Torres | 2 | 2 | 1 | - | - | - |
Jose Manuel Pinto | 2 | 2 | 13 | - | - | - |
Jeffren | 2 | - | 3 | 2 | - | - |
Oier Olazabal | 1 | 1 | - | - | - | - |
Alberto Botia | 1 | - | 4 | 1 | - | - |
Marc Muniesa | 1 | - | 1 | 1 | - | - |
Thiago Alcantara | 1 | - | 1 | 1 | - | - |
Abraham | 1 | - | 3 | 1 | - | - |
Albert Jorquera | - | - | 7 | - | - | - |
Andreau Fontas | - | - | 1 | - | - | - | 523 | 418 | 200 | 105 | 105 | 102 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .