| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Diego Lopez | 38 | 38 | - | - | - | - |
Joan Capdevila | 36 | 36 | - | - | 1 | 5 |
Joseba Llorente | 32 | 28 | 4 | 4 | 14 | 15 |
Sebastian Eguren | 32 | 28 | 4 | 4 | 8 | 1 |
Robert Pires | 32 | 24 | 8 | 8 | 16 | 3 |
Giuseppe Rossi | 30 | 28 | 4 | 2 | 18 | 12 |
Santi Cazorla | 30 | 26 | 4 | 4 | 5 | 8 |
Ariel Ibagaza | 30 | 19 | 13 | 11 | 14 | 1 |
Diego Godin | 29 | 29 | 1 | - | - | - |
Gonzalo Rodriguez | 27 | 27 | 1 | - | 1 | 2 |
Marcos Senna | 27 | 25 | 2 | 2 | 8 | 2 |
Bruno Soriano | 25 | 12 | 17 | 13 | 5 | - |
Javi Venta | 22 | 21 | 4 | 1 | 2 | - |
Angel Lopez | 21 | 19 | 10 | 2 | 1 | - |
Matias Fernandez | 21 | 5 | 23 | 16 | 4 | 3 |
Cani | 19 | 13 | 10 | 6 | 2 | 5 |
Nihat Kahveci | 19 | 8 | 14 | 11 | 6 | - |
Guillermo Franco | 18 | 5 | 16 | 13 | 5 | - |
Fabricio Fuentas | 16 | 14 | 11 | 2 | - | 2 |
Edmilson | 6 | 2 | 6 | 4 | 1 | - |
Jozy Altidore | 6 | 2 | 4 | 4 | 1 | 1 |
Pascal Cygan | 4 | 3 | 11 | 1 | - | - |
Marco Ruben | 3 | 3 | - | - | - | 1 |
Diego Cagna | 2 | 2 | - | - | - | - |
Jordi Pablo | 2 | - | 5 | 2 | - | - |
Javier Magro Matilla | 1 | 1 | 1 | - | - | - |
Joan Tomas | 1 | - | 1 | 1 | - | - |
Mario Gaspar | 1 | - | 1 | 1 | - | - |
Marcos Garcia | - | - | 1 | - | - | - |
Juan Carlos | - | - | 1 | - | - | - |
Sebastian Viera | - | - | 21 | - | - | - |
Marquez Cristobal | - | - | 1 | - | - | - | 530 | 418 | 199 | 112 | 112 | 61 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .