| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Brad Friedel | 38 | 38 | - | - | - | - |
Ashley Young | 37 | 37 | - | - | 3 | 5 |
Stilian Petrov | 37 | 37 | - | - | 4 | - |
Carlos Cuellar | 36 | 36 | 1 | - | - | 2 |
James Milner | 36 | 36 | 1 | - | 3 | 7 |
Gabriel Agbonlahor | 36 | 35 | 1 | 1 | 7 | 13 |
Richard Dunne | 35 | 35 | - | - | 1 | 3 |
John Carew | 33 | 22 | 12 | 11 | 15 | 10 |
Emile Heskey | 31 | 16 | 18 | 15 | 11 | 3 |
Stephen Warnock | 30 | 30 | 1 | - | 4 | - |
James Collins | 27 | 26 | 5 | 1 | - | 1 |
Stewart Downing | 25 | 23 | 3 | 2 | 5 | 2 |
Steve Sidwell | 25 | 12 | 25 | 13 | 2 | - |
Luke Young | 16 | 14 | 15 | 2 | 2 | - |
Nigel Reo-Coker | 10 | 6 | 18 | 4 | 5 | - |
Nathan Delfouneso | 9 | - | 25 | 9 | - | 1 |
Fabian Delph | 8 | 4 | 26 | 4 | 4 | - |
Habib Beye | 6 | 5 | 31 | 1 | 1 | - |
Nicky Shorey | 3 | 3 | 11 | - | - | - |
Marc Albrighton | 3 | - | 8 | 3 | - | - |
Curtis Davies | 2 | 2 | 5 | - | - | 1 |
Ciaran Clark | 1 | 1 | 7 | - | - | - |
Craig Gardner | 1 | - | 11 | 1 | - | - |
Brad Guzan | - | - | 38 | - | - | - |
Shane Lowry | - | - | 1 | - | - | - |
Moustapha Salifou | - | - | 3 | - | - | - | 485 | 418 | 266 | 67 | 67 | 48 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .