| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Patrice Evra | 38 | 37 | 1 | 1 | 4 | - |
Luis Antonio Valencia | 34 | 29 | 7 | 5 | 6 | 5 |
Dimitar Berbatov | 33 | 24 | 11 | 9 | 12 | 12 |
Wayne Rooney | 32 | 32 | - | - | 10 | 26 |
Darren Fletcher | 30 | 29 | 5 | 1 | 5 | 4 |
Michael Carrick | 30 | 22 | 12 | 8 | 3 | 2 |
Paul Scholes | 28 | 24 | 8 | 4 | 11 | 3 |
Ryan Giggs | 25 | 20 | 6 | 5 | 7 | 5 |
Nemanja Vidic | 24 | 24 | 2 | - | 2 | 1 |
Nani | 23 | 19 | 8 | 4 | 7 | 4 |
Edwin van der Sar | 21 | 21 | - | - | - | - |
Wes Brown | 19 | 18 | 6 | 1 | 2 | - |
Michael Owen | 19 | 5 | 22 | 14 | 4 | 3 |
Jonny Evans | 18 | 18 | 8 | - | 2 | - |
Gary Neville | 17 | 15 | 9 | 2 | 2 | - |
Ji Sung Park | 17 | 10 | 16 | 7 | 7 | 3 |
John O'Shea | 15 | 12 | 5 | 3 | 1 | 1 |
Darron Gibson | 15 | 6 | 16 | 9 | 4 | 2 |
Anderson | 14 | 10 | 11 | 4 | 7 | 1 |
Rio Ferdinand | 13 | 12 | 2 | 1 | - | - |
Ben Foster | 9 | 9 | 12 | - | - | - |
Rafael Da Silva | 8 | 8 | 8 | - | 2 | 1 |
Tomasz Kuszczak | 8 | 8 | 24 | - | - | - |
Gabriel Obertan | 7 | 1 | 13 | 6 | 1 | - |
Fabio Da Silva | 5 | 1 | 15 | 4 | - | - |
Federico Macheda | 5 | 1 | 6 | 4 | 1 | 1 |
Danny Welbeck | 5 | 1 | 8 | 4 | 1 | - |
Mame Diouf | 5 | - | 6 | 5 | - | 1 |
Ritchie de Laet | 2 | 2 | 12 | - | 1 | - |
Owen Hargreaves | 1 | - | 2 | 1 | - | - |
Ben Amos | - | - | 2 | - | - | - |
Oliver Gill | - | - | 1 | - | - | - |
Corry Evans | - | - | 1 | - | - | - |
Zoran Tosic | - | - | 1 | - | - | - | 520 | 418 | 266 | 102 | 102 | 75 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .