| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Fernando Muslera | 36 | 36 | - | - | - | - |
Stefano Mauri | 35 | 29 | 6 | 6 | 8 | 3 |
Aleksandar Kolarov | 33 | 33 | - | - | - | 3 |
Stephen Lichtsteiner | 33 | 28 | 6 | 5 | 8 | 2 |
Tommaso Rocchi | 32 | 23 | 12 | 9 | 14 | 6 |
Mauro Zarate | 31 | 27 | 6 | 4 | 3 | 3 |
Stefan Radu | 28 | 28 | 5 | - | - | - |
Christian Brocchi | 27 | 25 | 3 | 2 | 5 | 2 |
Roberto Baronio | 24 | 22 | 9 | 2 | 7 | - |
Julio Cruz | 24 | 8 | 20 | 16 | 4 | 4 |
Sebastiano Siviglia | 20 | 18 | 6 | 2 | 6 | 1 |
Guglielmo Stendardo | 19 | 19 | 3 | - | 1 | 2 |
Modibo Diakite | 19 | 11 | 21 | 8 | 3 | - |
Sergio Floccari | 18 | 17 | - | 1 | 8 | 8 |
Matuzalem | 18 | 14 | 4 | 4 | 6 | 1 |
Pasquale Foggia | 16 | 9 | 12 | 7 | 8 | - |
Cristian Ledesma | 13 | 13 | - | - | 1 | - |
Giuseppe Biava | 13 | 10 | 5 | 3 | 2 | - |
Andre Dias | 12 | 12 | 1 | - | - | 2 |
Fabio Firmani | 12 | 8 | 9 | 4 | 3 | - |
Ousmane Dabo | 12 | 6 | 8 | 6 | 4 | - |
Emilson Cribari | 10 | 7 | 7 | 3 | 2 | - |
Simone Del Nero | 7 | 6 | 10 | 1 | 6 | - |
Mourad Meghni | 7 | 3 | 8 | 4 | 2 | - |
Thomas Hitzlsperger | 6 | 2 | 11 | 4 | 2 | 1 |
Lionel Scaloni | 5 | 1 | 11 | 4 | - | - |
Simone Inzaghi | 3 | - | 12 | 3 | - | - |
Tommaso Berni | 2 | 2 | 24 | - | - | - |
Riccardo Perpetuini | 2 | 1 | 4 | 1 | 1 | - |
Ayodele Stephen Makinwa | 2 | - | 10 | 2 | - | - |
Eliseu | 2 | - | 11 | 2 | - | - |
Alessio Luciani | 1 | - | 3 | 1 | - | - |
Federico Sevieri | - | - | 1 | - | - | - |
Antony Iannarilli | - | - | 2 | - | - | - |
Albano Bizzarri | - | - | 11 | - | - | - |
Marco Davide Faraoni | - | - | 1 | - | - | - | 522 | 418 | 262 | 104 | 104 | 38 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .