| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Julio Cesar | 38 | 38 | - | - | - | - |
Javier Zanetti | 37 | 37 | - | - | - | - |
Diego Milito | 35 | 33 | 3 | 2 | 12 | 22 |
Maicon | 33 | 33 | - | - | - | 6 |
Samuel Eto'o | 32 | 27 | 5 | 5 | 7 | 12 |
Lucio | 31 | 30 | 5 | 1 | 3 | 1 |
Esteban Cambiasso | 30 | 26 | 4 | 4 | 9 | 3 |
Dejan Stankovic | 29 | 24 | 5 | 5 | 8 | 3 |
Walter Samuel | 28 | 25 | 7 | 3 | 3 | 3 |
Sulley Muntari | 27 | 16 | 13 | 11 | 13 | 1 |
Wesley Sneijder | 26 | 24 | 2 | 2 | 11 | 4 |
Thiago Motta | 26 | 18 | 9 | 8 | 12 | 4 |
Mario Balotelli | 26 | 13 | 15 | 13 | 9 | 9 |
Ivan Cordoba | 21 | 15 | 20 | 6 | 1 | - |
Cristian Chivu | 20 | 16 | 7 | 4 | 4 | 1 |
Goran Pandev | 19 | 13 | 6 | 6 | 8 | 3 |
Davide Santon | 12 | 8 | 8 | 4 | 2 | - |
Patrick Vieira | 12 | 7 | 10 | 5 | 4 | 1 |
Marco Materazzi | 12 | 7 | 19 | 5 | 1 | - |
Ricardo Quaresma | 11 | 3 | 20 | 8 | 2 | - |
McDonald Mariga | 8 | 3 | 12 | 5 | 1 | 1 |
Mancini | 6 | 1 | 13 | 5 | - | - |
Rene Krhin | 5 | 1 | 14 | 4 | 1 | - |
Marko Arnautovic | 3 | - | 13 | 3 | - | - |
Alen Stevanovic | 1 | - | 2 | 1 | - | - |
David Suazo | 1 | - | 7 | 1 | - | - |
Sebastian Carlsen | - | - | 1 | - | - | - |
Paulo Orlandoni | - | - | 5 | - | - | - |
Giulio Donati | - | - | 4 | - | - | - |
Denis Alibec | - | - | 1 | - | - | - |
Lorenzo Crisetig | - | - | 2 | - | - | - |
Francesco Toldo | - | - | 34 | - | - | - | 529 | 418 | 266 | 111 | 111 | 74 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .