| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 John Arne Riise | 36 | 34 | 2 | 2 | 1 | 5 |
Mirko Vucinic | 34 | 32 | 2 | 2 | 19 | 14 |
Daniele De Rossi | 33 | 33 | 1 | - | 5 | 7 |
Nicolas Burdisso | 32 | 31 | 2 | 1 | - | 2 |
Simone Perrotta | 32 | 31 | 3 | 1 | 5 | 5 |
Rodrigo Taddei | 32 | 25 | 8 | 7 | 8 | 2 |
David Pizarro | 31 | 31 | 1 | - | 4 | 2 |
Julio Sergio | 30 | 30 | 2 | - | 1 | - |
Juan | 29 | 28 | 2 | 1 | 3 | - |
Marco Cassetti | 29 | 26 | 8 | 3 | 5 | 2 |
Matteo Brighi | 24 | 15 | 19 | 9 | 5 | 4 |
Francesco Totti | 23 | 21 | 2 | 2 | 7 | 14 |
Jeremy Menez | 23 | 18 | 13 | 5 | 15 | 1 |
Julio Baptista | 23 | 4 | 25 | 19 | 4 | 3 |
Philippe Mexes | 19 | 16 | 14 | 3 | 2 | 1 |
Marco Motta | 16 | 13 | 16 | 3 | 7 | - |
Luca Toni | 15 | 10 | 6 | 5 | 4 | 5 |
Alessio Cerci | 9 | 2 | 21 | 7 | 2 | - |
Ricardo Faty | 9 | 2 | 16 | 7 | 2 | - |
Marco Andreolli | 8 | 4 | 14 | 4 | 1 | - |
Doni | 7 | 7 | 14 | - | - | - |
Stefano Okaka | 7 | - | 14 | 7 | 1 | 1 |
Stefano Guberti | 6 | 3 | 9 | 3 | 1 | - |
Max Tonetto | 4 | - | 16 | 4 | - | - |
Cicinho | 2 | - | 3 | 2 | - | - |
Bogdan Lobont | 2 | - | 18 | 2 | - | - |
Adrian Pit | 2 | - | 3 | 2 | - | - |
Artur Moraes | 1 | 1 | 3 | - | - | - |
Aleandro Rosi | 1 | 1 | - | - | - | - |
Stefano Pettinari | 1 | - | 1 | 1 | - | - |
Vitorino Antunes | - | - | 2 | - | - | - |
Leandro Greco | - | - | 1 | - | - | - | 520 | 418 | 261 | 102 | 102 | 68 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .