| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Iker Casillas | 38 | 38 | - | - | - | - |
Marcelo | 35 | 34 | 3 | 1 | 5 | 4 |
Xabi Alonso | 34 | 34 | - | - | 7 | 3 |
Sergio Ramos | 33 | 33 | - | - | 1 | 4 |
Raul Albiol | 33 | 32 | 4 | 1 | - | - |
Gonzalo Higuain | 32 | 28 | 6 | 4 | 16 | 27 |
Esteban Granero | 31 | 21 | 15 | 10 | 12 | 3 |
Alvaro Arbeloa | 30 | 30 | 3 | - | 2 | 2 |
Raul | 30 | 8 | 25 | 22 | 6 | 5 |
Cristiano Ronaldo | 29 | 28 | 1 | 1 | 4 | 26 |
Karim Benzema | 27 | 14 | 15 | 13 | 10 | 8 |
Rafael van der Vaart | 26 | 16 | 11 | 10 | 14 | 6 |
Guti | 26 | 10 | 16 | 16 | 5 | 2 |
Kaka | 25 | 21 | 4 | 4 | 14 | 8 |
Lassana Diarra | 22 | 19 | 9 | 3 | 4 | 1 |
Ezequiel Garay | 20 | 19 | 14 | 1 | 2 | 1 |
Fernando Gago | 18 | 14 | 16 | 4 | 5 | - |
Mahamadou Diarra | 16 | 4 | 24 | 12 | 1 | - |
Pepe | 10 | 10 | - | - | 1 | 1 |
Roysten Drenthe | 8 | 3 | 19 | 5 | 1 | - |
Christoph Metzelder | 2 | 2 | 23 | - | - | - |
Ruud van Nistelrooy | 1 | - | 4 | 1 | - | 1 |
Pedro Mosquera | 1 | - | 4 | 1 | - | - |
Marcos Alonso | 1 | - | 2 | 1 | - | - |
David Mateos | - | - | 2 | - | - | - |
Rodrigo Moreno | - | - | 1 | - | - | - |
Javier Acuna | - | - | 2 | - | - | - |
Marcos Tebar | - | - | 1 | - | - | - |
Jerzy Dudek | - | - | 37 | - | - | - |
Antonio Adan | - | - | 1 | - | - | - |
Juanfran | - | - | 2 | - | - | - | 528 | 418 | 264 | 110 | 110 | 102 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .