| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Ever Banega | 37 | 33 | 3 | 4 | 12 | 2 |
Juan Mata | 35 | 30 | 8 | 5 | 12 | 9 |
Pablo Hernandez | 33 | 25 | 10 | 8 | 10 | 5 |
David Villa | 32 | 31 | 2 | 1 | 6 | 22 |
Cesar Sanchez | 30 | 30 | 7 | - | - | - |
David Silva | 29 | 27 | 4 | 2 | 8 | 7 |
David Albelda | 28 | 22 | 7 | 6 | 8 | 1 |
Joaquin | 28 | 17 | 16 | 11 | 9 | 2 |
Bruno Saltor | 26 | 25 | 1 | 1 | 5 | - |
Miguel | 25 | 20 | 9 | 5 | 5 | - |
Angel Dealbert | 24 | 22 | 5 | 2 | 2 | - |
Alexis | 24 | 21 | 8 | 3 | - | 1 |
Carlos Marchena | 24 | 17 | 11 | 7 | 6 | 2 |
David Navarro | 19 | 19 | 7 | - | 2 | 2 |
Hedwiges Maduro | 18 | 12 | 16 | 6 | 2 | - |
Ruben Baraja | 18 | 8 | 21 | 10 | 4 | - |
Jeremy Mathieu | 17 | 14 | 6 | 3 | 5 | 1 |
Manuel Fernandes | 15 | 8 | 10 | 7 | 2 | - |
Jordi Alba | 14 | 12 | 8 | 2 | 2 | 1 |
Nikola Zigic | 13 | 5 | 30 | 8 | 1 | 4 |
Alejandro Dominguez | 13 | 4 | 13 | 9 | 3 | - |
Vicente | 11 | 5 | 9 | 6 | 4 | - |
Miguel Angel Moya | 8 | 8 | 29 | - | - | - |
Michel | 3 | - | 7 | 3 | - | - |
Nicolas Fedor | 2 | 1 | 4 | 1 | 1 | - |
Joel Johnson | 1 | 1 | 2 | - | - | - |
Lillo | 1 | 1 | 3 | - | 1 | - |
Asier Del Horno | - | - | 1 | - | - | - |
Isco | - | - | 1 | - | - | - |
Carles Martinez | - | - | 1 | - | - | - |
Vicente Guaita | - | - | 3 | - | - | - |
Dani Hernandez | - | - | 1 | - | - | - |
Miguel Angel Angulo | - | - | 1 | - | - | - |
Victor Fernandez | - | - | 1 | - | - | - | 528 | 418 | 265 | 110 | 110 | 59 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .