| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Diego Lopez | 38 | 38 | - | - | - | - |
Joan Capdevila | 37 | 37 | - | - | - | 5 |
Cani | 37 | 27 | 10 | 10 | 19 | 2 |
Diego Godin | 36 | 36 | - | - | 1 | 3 |
Giuseppe Rossi | 34 | 27 | 7 | 7 | 13 | 10 |
Bruno Soriano | 33 | 31 | 4 | 2 | 4 | - |
Nilmar | 33 | 28 | 7 | 5 | 10 | 11 |
Marcos Senna | 30 | 26 | 5 | 4 | 9 | 1 |
Joseba Llorente | 29 | 20 | 15 | 9 | 12 | 9 |
Robert Pires | 28 | 13 | 20 | 15 | 8 | 4 |
Angel Lopez | 24 | 22 | 13 | 2 | 3 | 1 |
Santi Cazorla | 24 | 16 | 9 | 8 | 5 | 5 |
Ariel Ibagaza | 24 | 14 | 12 | 10 | 12 | 2 |
David Fuster | 22 | 11 | 19 | 11 | 9 | 3 |
Gonzalo Rodriguez | 21 | 19 | 9 | 2 | - | - |
Javi Venta | 18 | 16 | 15 | 2 | 1 | - |
Ivan Marcano | 16 | 15 | 13 | 1 | 2 | 1 |
Sebastian Eguren | 14 | 9 | 8 | 5 | 1 | - |
Damian Escudero | 13 | 3 | 20 | 10 | 3 | 1 |
Mateo Musacchio | 7 | 5 | 9 | 2 | - | - |
Jonathan Pereira | 6 | - | 13 | 6 | - | - |
Javier Magro Matilla | 2 | 2 | 2 | - | 1 | - |
Kiko Olivas | 2 | 2 | 3 | - | - | - |
Marcos Gullon | 2 | 1 | 7 | 1 | - | - |
Marco Ruben | 1 | - | 1 | 1 | - | - |
Jefferson Montero | - | - | 1 | - | - | - |
Xavi Oliva | - | - | 38 | - | - | - |
Fabricio Fuentas | - | - | 2 | - | - | - |
Hernan Perez | - | - | 1 | - | - | - |
Jose Catala | - | - | 2 | - | - | - | 531 | 418 | 265 | 113 | 113 | 58 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .