| Players | Total | Start | Sub | CO | Off | Goals |
|---|---|---|---|---|---|---|
 Jose Manuel Jurado | 38 | 29 | 9 | 9 | 10 | 7 |
Simao Sabrosa | 34 | 30 | 4 | 4 | 15 | 2 |
Diego Forlan | 33 | 30 | 5 | 3 | 13 | 18 |
Antonio Lopez | 31 | 29 | 5 | 2 | 3 | 2 |
Paulo Assuncao | 30 | 29 | 3 | 1 | 7 | 1 |
Sergio Aguero | 30 | 24 | 8 | 6 | 13 | 12 |
Jose Antonio Reyes | 30 | 19 | 14 | 11 | 12 | 2 |
Tomas Ujfalusi | 28 | 27 | 3 | 1 | - | - |
Luis Perea | 28 | 27 | 5 | 1 | 1 | - |
Alvaro Dominguez | 26 | 26 | 6 | - | 2 | - |
Juan Valera | 23 | 19 | 15 | 4 | 5 | - |
Raul Garcia | 21 | 12 | 16 | 9 | 6 | - |
David de Gea | 19 | 19 | 15 | - | - | - |
Tiago | 18 | 16 | 3 | 2 | 2 | 2 |
Ibrahima Balde | 18 | 5 | 19 | 13 | 2 | 3 |
Juanito | 17 | 15 | 19 | 2 | - | 2 |
Sergio Asenjo | 15 | 15 | 16 | - | 1 | - |
Maxi Rodriguez | 14 | 9 | 6 | 5 | 8 | 2 |
Cleber Santana | 14 | 8 | 7 | 6 | 1 | 1 |
Ignacio Camacho | 12 | 6 | 20 | 6 | 1 | - |
Eduardo Salvio | 12 | 5 | 11 | 7 | 1 | 2 |
Florent Sinama-Pongolle | 10 | 3 | 10 | 7 | 3 | - |
Pablo Ibanez | 6 | 5 | 10 | 1 | 1 | - |
Leandro Cabrera | 4 | 4 | 7 | - | - | - |
Roberto Gago | 3 | 3 | 2 | - | - | - |
Jorge Koke | 3 | 1 | 5 | 2 | - | - |
Joel Robles | 2 | 1 | 2 | 1 | - | - |
Keko | 2 | - | 3 | 2 | - | - |
Mariano Pernia | 1 | 1 | 5 | - | - | - |
John Heitinga | 1 | 1 | - | - | - | - |
Ruben Perez | 1 | - | 5 | 1 | - | - |
Jorge Molino | 1 | - | 1 | 1 | - | - |
Borja Gonzalez | 1 | - | 2 | 1 | 1 | - |
Sergio Rodriguez | - | - | 2 | - | - | - |
Sebastian Gallegos | - | - | 1 | - | - | - | 526 | 418 | 264 | 108 | 108 | 56 |
Total = Total appearances,
Start = Total started,
CO = Came on,
Sub = Started as a sub,
Off = Taken off .